This work aims to assess the S65487-induced disruption of the B-cell lymphoma-2 (Bcl2)/Bcl2-like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear 3-compartment pharmacokinetic model linked to an...
ObesityJune 4, 2026Abigail B. Lodrigues, Alissa V. Russell, Shelby Tungate Lopez et al.
A.M.K. has received advisory/consulting fees from Camurus Pharmaceuticals, Dexcom Inc., Eli Lilly and Company, and Lexidrug/Wolters-Kluwer. A.B.L., A.V.R., and S.T.L. declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.
Background: Traumatic brain injury (TBI) can result in prolonged post-concussive syndrome and chronic hypoxic-ischemic brain injury (HIBI) sequelae remains therapeutically challenging with the persistence of significant neurological and cognitive impairments. While conventional treatments often provide limited relief, emerging research explores alternative therapeutic interventions, including...
Expanded use of buprenorphine-naloxone use, particularly for marginalized communities, such as the unhoused, is an established priority. Unfortunately, due to fear of the precipitation of opioid withdrawal, this goal remains unmet. In response, microdosing methods during the initial week of treatment do not require opioid abstinence and do not precipitate withdrawal. This review establishes the...
An increasing number of U.S. states are implementing or considering alternative policies to the prohibition of some psychedelic substances for nonclinical purposes. The authors present new data and analysis to inform these discussions with survey results on the use of 11 psychedelic substances and detailed information about the prevalence of microdosing (i.e., taking a fraction of a full dose,...
Purpose Current laws prohibiting access to illicit drugs contribute to drug harms as manufacturers and distributors of illicit substances have variable influence over drug supply and quality. Legislation introduced in New Zealand (NZ) in 2021 aimed to address such harm by enabling licenced drug checking providers to directly analyse samples from consumers. This paper aims to detail the use of...
ABSTRACT: The recent resolution of semaglutide and tirzepatide shortages by the US Food and Drug Administration (FDA) has fundamentally altered the regulatory landscape for compounded obesity medications. Despite recent federal pricing agreements to reduce GLP-1 costs, ongoing affordability barriers continue to drive patient desperation, fueling a shift toward unsupervised strategies such as...
Electroencephalographic (EEG) microstates provide a compact framework for characterizing the temporal organization of large-scale brain activity, yet their sensitivity to altered brain states remains insufficiently explored. In this study, we applied broadband and frequency-resolved EEG microstate analysis to resting-state EEG data from two publicly available datasets acquired under markedly...
The development of lung-directed therapeutics is limited by poor translational fidelity between preclinical models and early-phase clinical trials. We report a first-in-human Phase 0 intratarget microdosing study demonstrating the feasibility of intrapulmonary delivery and pharmacological interrogation of a novel inflammasome inhibitor. A 100 μg microdose of ADS032, a dual NLRP1/NLRP3...
This study compared the effects of low-frequency flywheel resistance training (FRT, 1 session/week) and microdosing FRT (5 sessions/week) on muscle architecture, strength, and vertical jump performance in active individuals. Thirty participants were randomized into a microdosing group (MDG, n = 15) or a control group (CG, n = 15). Both groups completed equalized weekly training volumes (30 sets...