Exploratory Research in Clinical and Social Pharmacy
February 4, 2026
Shreya Shiju, Rohan Tirumala, Elliot Marseille
Background: As public and scientific interest in psychedelics grows, unsupervised use for health purposes is increasing. In the U.S., past-year hallucinogen use nearly doubled from 2015 to 2023. Many individuals report self-treating physical or psychological symptoms without medical supervision using psychedelics—a practice termed self-medication. Despite this trend, review-level syntheses...
European Neuropsychopharmacology
February 1, 2026
Isabel Werle, Francisco S Guimarães, Rafael G. Dos Santos et al.
Rodent studies have shown that psychedelic drugs can enhance fear extinction. However, investigations to date have relied on normative aversive conditioning procedures, which limit their relevance to trauma-related memories, as these tend to be overgeneralized and resistant to extinction. Fear extinction depends on activity and plasticity within the infralimbic (IL) region of the medial...
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
February 1, 2026
Katarzyna Kała, Dorota Bederska‐łojewska, Jan Lazur et al.
The growing percentage of people suffering from drug-resistant depression increases interest in alternative therapies, particularly the usage of psychedelics such as psilocybin. The main source of psilocybin is the Psilocybe cubensis species. Due to the potential therapeutic benefits of psilocybin and the legal restrictions on its possession and use in the form of fungal fruiting bodies, this...
Mental Health Weekly
January 23, 2026
Valerie A. Canady
Microdosing — once a niche practice whispered about in online forums and tech circles — has firmly entered the mainstream. A new RAND survey suggests that millions of U.S. adults are now taking sub‐perceptual amounts of psychedelics such as psilocybin, LSD and MDMA, often with goals that differ sharply from those associated with traditional, full‐dose use.
Soil use and management
2026
Yacouba Ouedraogo, J. Taonda, Idriss Sermé et al.
Fertiliser microdosing (FM) is widely promoted in sub‐Saharan Africa as a means to improve fertiliser use efficiency in cereal crops. However, combining organic amendments with FM could further increase the agronomic efficiency of the latter because of possible synergies between both practices. This study therefore evaluated whether combining FM with organic amendments enhanced fertiliser use...
International Journal of Agronomy
2026
Parwada Cosmas, Masere T. Philip, Gumbo Albert
The small‐scale farmers of semiarid southern Africa are experiencing chronic water and nutrient shortages due to climate change; however, very few initiatives have been put in place to optimize the production of underutilized drought‐tolerant small grains that currently give poor yields of less than 0.8 t ha −1 using conventional planting techniques. The current experiment was undertaken to...
Human Enhancement Drugs Volume Two
2026
Microdosing psychedelics has attracted growing attention from public commentators, scientists, investors and user communities across the globe. Microdosing is the use of small doses of psychedelic substances such as psilocybin mushrooms and LSD. Its proponents speak of microdosing as a use modality that improves various human abilities and life areas, including cognitive function, mood,...
Neuropharmacology
2026
Luisa Prochazkova, Laura C. Carvalho, Natasza Marrouch et al.
While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting. A retrospective mixed-method survey was conducted with 365...
Neuroscience & Biobehavioral Reviews
2026
Netta Pinhas, Nofar Eidlman, Avigail Barnea et al.
2 citations
Microdosing - the practice of consuming extremely low doses of classical psychedelic substances that do not elicit overt psychedelic effects - has gained significant attention as a potential method for enhancing cognitive performance. However, findings from controlled studies remain mixed and inconclusive. This preregistered meta-analysis examined the cognitive effects of classical psychedelic...
Palliative & Supportive Care
2026
Fiona Cottam, Alesha Wells, Cerys Clayden et al.
Participation in trials investigating psychedelic-assisted MCP may offer hope for patients and their caregivers. Given the bidirectional relationship in wellbeing between cancer dyads, caregivers should be included alongside patients in such trials.