2022
Amanda Medeiros Furquim, Tânia Marcourakis
INTRODUÇÃO: O Transtorno de Estresse Pós-Traumático (TEPT) é um transtorno neuropsiquiátrico que se desencadeia após a experiência ou testemunho de um evento psicologicamente traumático. Este distúrbio representa um grande problema de saúde pública mundial, afetando mais de 8 milhões de americanos e custando cerca de US{dollar} 43,2 bilhões por ano aos EUA. Os tratamentos existentes consistem...
Handbook of Substance Misuse and Addictions
2022
Esther Papaseit, Magí Farré, Clara Pérez‐mañá
Public health focused on drug use is considered a balancing act between preventing illicit use of drugs of abuse and ensuring access to drugs/medicines with abuse potential for a medical condition. Whereas clinically relevant drug interactions for medicines are widely recognized and are included in most pharmacovigilance systems, drug interactions with drugs of abuse are mainly underexplored,...
Handbook of Substance Misuse and Addictions
2022
Francis Kin Chiu Chu
MDMA (3,4-methylenedioxymethamphetamine), popularly known as “ecstasy,” “E,” “Adam,” “XTC,” “M&M,” or “Molly,” is a synthetic compound of phenethylamine with stimulant and hallucinogenic properties. It is a common recreational street drug affecting young people particularly at urban dance parties in Hong Kong. MDMA abuse is widely reported in electronic dance music (EDM) festivals all over the...
HPHR Journal
2022
Candice Carpenter
According to the National Survey on Drug Use and Health, in just 2014 alone, over 17 million persons ages 12 or older reported at least a singular lifetime use of the hallucinogenic stimulant, and well-known recreational drug, MDMA, or 3,4- methylenedioxymethamphetamine. Compared to 10 years prior, this was an increase from 11 million people within the same age bracket.21Per the European Centre...
2022
Davi Mello Castanheira, Andréa da Silva Torrão
INTRODUÇÃO: O Transtorno de Estresse Pós-Traumático (TEPT) é definido como uma condição na qual um indivíduo que sofreu um evento traumático revisita a experiência na forma de lembranças, sonhos ou episódios dissociativos de flashback. A psicoterapia é considerada como primeira opção para o tratamento de TEPT, mas também se utiliza a farmacoterapia com os ISRS paroxetina e sertralina. Os...
Journal of Psychopharmacology
2022
Grant Jones, Matthew K. Nock
40 citations
Background: Depression is a major mental health issue worldwide, with high rates of chronicity and non-recovery associated with the condition. Existing treatments such as antidepressant medication and psychological treatments have modest effectiveness, suggesting the need for alternative interventions. Aim: The aim of this study was to examine the relationships between MDMA...
Journal of Psychopharmacology
2022
Grant Jones, Matthew K. Nock
60 citations
Background: Suicide is one of the leading causes of death worldwide and rates within the United States have risen over the past two decades. Hence, there is a critical need for novel tools to treat suicidal ideation and related mental health conditions. 3,4-Methylenedioxymethamphetamine (MDMA)/ecstasy and classic psychedelics may be two such tools. Aims: The aim of this study was to assess...
Frontiers in Psychiatry
2022
S Parker Singleton, Julie B. Wang, Michael C Mithoefer et al.
36 citations
3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) for post-traumatic stress disorder (PTSD) has demonstrated promise in multiple clinical trials. MDMA is hypothesized to facilitate the therapeutic process, in part, by decreasing fear response during fear memory processing while increasing extinction learning. The acute administration of MDMA in healthy controls modifies recruitment...
Current Topics in Behavioral Neurosciences
2022
Matthias E. Liechti, Friederike Holze
35 citations
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and posttraumatic stress disorder, among others....
ACS Omega
December 20, 2021
Jay B. Nair, Linda B Hakes, Berra Yazar-Klosinski et al.
12 citations
MDMA is increasingly used in clinical research, but no cGMP process has yet been reported. We describe here the first fully validated cGMP synthesis of up to 5 kg (≈30 000 patient doses) of MDMA in a four-step process beginning with a noncontrolled starting material. The overall yield was acceptable (41-53%, over four steps), and the chemical purity of the final product was excellent, exceeding...