Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA
ACS Omega December 20, 2021 Jay B. Nair, Linda B Hakes, Berra Yazar-Klosinski et al. 12 citations
MDMA is increasingly used in clinical research, but no cGMP process has yet been reported. We describe here the first fully validated cGMP synthesis of up to 5 kg (≈30 000 patient doses) of MDMA in a four-step process beginning with a noncontrolled starting material. The overall yield was acceptable (41-53%, over four steps), and the chemical purity of the final product was excellent, exceeding...