Psychedelics
April 20, 2026
José Carlos Bouso, Óscar Andión, Jordi Cantillo et al.
The Symmetrical Global Mental Health (Sym-GMH) paradigm proposes a reciprocal integration between traditional and Western medical systems. This prospective, longitudinal study evaluates the psychological outcomes of 264 Western participants who engaged in Shipibo-led ayahuasca retreats at the Temple of the Way of Light in the Peruvian Amazon. Over a 12-month period, participants completed...
Scientific Reports
September 1, 2025
Oscar Soto-Angona, Óscar Andión, Pablo Sabucedo et al.
3 citations
Preliminary evidence suggests that ayahuasca may alleviate severe grief symptoms. This three-arm, sequentially allocated, open-label study examines the therapeutic changes associated with ayahuasca-assisted meaning reconstruction therapy (A-MR) compared to meaning reconstruction therapy alone (MR) and a no-treatment control (NT). A total of 84 adults experiencing severe grief within 12 months...
Frontiers in Pharmacology
2025
Georgina de la Rosa, Esther Papaseit, Olga Hladun et al.
7 citations
Alpha-pyrrolidinopentiophenone (α-PVP) is a commonly consumed analogue of pyrovalerone, a synthetic cathinone with psychostimulant properties similar to those of 3,4-Methylenedioxypyrovalerone (MDPV) and cocaine. Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration. We...
Frontiers in Psychiatry
2025
Pablo Sabucedo, Óscar Andión, Robert A Neimeyer et al.
correction
1 IntroductionGrieving the death of a loved one is a nearly universal experience, and one which may be experienced multiple times over the course of a lifetime. Recent studies have shown that, for each death, approximately nine relatives are directly affected (1). The loss of a first-degree family member significantly increases the risk of mortality, disease, and suicide for the mourner (2–6)....
Journal of Pharmaceutical and Biomedical Analysis
January 20, 2024
Alfredo Fabrizio Lo Faro, Giorgia Sprega, Diletta Beradinelli et al.
14 citations
In the present study enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its major phase-1 metabolites 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat,...
Frontiers in Psychiatry
2024
Pablo Sabucedo, Óscar Andión, Robert A Neimeyer et al.
4 citations
Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased attention over the past decades. Evidence-based approaches to prevent PGD are currently scarce, and not always effective. This paper introduces a protocol for a clinical trial exploring the effectiveness of a Meaning Reconstruction psychotherapy...
Handbook of Substance Misuse and Addictions
2022
Esther Papaseit, Magí Farré, Clara Pérez‐mañá
Public health focused on drug use is considered a balancing act between preventing illicit use of drugs of abuse and ensuring access to drugs/medicines with abuse potential for a medical condition. Whereas clinically relevant drug interactions for medicines are widely recognized and are included in most pharmacovigilance systems, drug interactions with drugs of abuse are mainly underexplored,...
Frontiers in Pharmacology
January 28, 2020
Esther Papaseit, Clara Pérez‐mañá, Elizabeth B. de Sousa Fernandes Perna et al.
27 citations
Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol). The aim of the present study was to evaluate the interactions on subjective, cardiovascular and hormone effects and pharmacokinetics between mephedrone and alcohol in humans. Eleven male volunteers participated as...
Human Psychopharmacology
July 1, 2013
Débora González, Mireia Ventura, Fernando Caudevilla et al.
39 citations
To know the pattern of use of new psychoactive substances (NPSs) in a Spanish sample of research chemical (RC) users and to deepen the RC user profile and risk reduction strategies employed. This study is a cross-sectional survey by means of a specific questionnaire. Recruitment was carried out at music festivals, at non-governmental organizations (NGOs), and through announcements on an online...
Journal of psychopharmacology (Oxford, England)
July 1, 2012
Fernando Caudevilla-Gálligo, Jordi Riba, Mireia Ventura et al.
99 citations
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive analogue of mescaline that is becoming increasingly popular as a rave and club drug. We investigated its presence in the illicit drug market in Spain, its pattern of use and profile of subjective effects. Drug material was analysed for 2C-B and information on pattern of use and subjective effects was obtained from recreational users....
International Journal of Culture and Mental Health
December 1, 2009
Fabrizio Schifano, Ornella Corazza, Paolo Deluca et al.
79 citations
The aim of the study was to foster the collection and analysis of data from web pages related to information on the consumption, manufacture and sale of Spice products, a brand name for an herbal smoking blend, sold as legal substitute for cannabis. The Google search engine was used to carry out an 8-language qualitative assessment of information available on Spice products in a sample of about...
Journal of Pharmaceutical and Biomedical Analysis
June 9, 2008
Simona Pichini, Mitona Pujadas, Emilia Marchei et al.
59 citations
A procedure based on liquid chromatography-mass spectrometry (LC-MS) is described for determination of 3,4-methylenedioxymethamphetamine (MDMA), 2,5-dimethoxy-4-methyl-phenethylamine (2C-D), 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B), 1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b'] difuran-4-yl)-2-aminoethane (2C-B-Fly), 4-ethylthio-2,5-dimethoxy-beta-phenethylamine (2C-T-2),...
Rapid communications in mass spectrometry : RCM
2005
Simona Pichini, Sergio Abanades, Magí Farré et al.
58 citations
A gas chromatography method with mass spectrometric detection is described for the determination of Salvinorin A, the main active ingredient of the hallucinogenic mint Salvia divinorum. The method was validated in plasma, urine, saliva and sweat using 17-alpha-methyltestosterone as internal standard. The analytes were extracted from biological matrices with chloroform/isopropanol (9:1, v/v)....
Clinical Chemistry
October 1, 2001
Mèonica Navarro, Simona Pichini, Magí Farré et al.
135 citations
Abstract Background: Saliva is an alternative biologic matrix for drugs-of-abuse testing that offers the advantages of noninvasive, rapid, and easy sampling. We studied the excretion profile of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in both saliva and plasma, as well the effect of the drug on salivary pH. Methods: Saliva and plasma samples were obtained from eight healthy...