Journal of Psychopharmacology
February 18, 2021
Ben Sessa, Laurie Higbed, Steve O’Brien et al.
123 citations
Background: 3,4-methylenedioxymethamphetamine (MDMA) therapy has qualities that make it potentially well suited for patients with addictions, but this has never been explored in a research study. We present data from the Bristol Imperial MDMA in Alcoholism (BIMA) study. This is the first MDMA addiction study, an open-label safety and tolerability proof-of-concept study investigating the...
Neuropharmacology
February 16, 2021
C. Abuin-Martínez, Rebeca Vidal, Maria D Gutierrez-Lopez et al.
3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has been shown to produce serotonergic damage in the brains of primates, including humans, and of rats. Tryptophan, the precursor of serotonin, is primarily degraded through the kynurenine (KYN) pathway, producing among others KYN, the main metabolite of this route. KYN has been reported as an endogenous agonist of the...
Mental Health Weekly
February 15, 2021
Valerie A. Canady
Prior use of selective serotonin reuptake inhibitors (SSRIs) may reduce the effectiveness of 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted therapy for post‐traumatic stress disorder (PTSD), say researchers of a recent study who noted that MDMA is close to being considered the first psychedelic drug approved to treat PTSD.
Libro Comunicaciones
2021
Objetivos: El trastorno por déficit de atención e hiperactividad es uno de los trastornos más diagnosticados en niños, adolescentes y adultos jóvenes. El mecanismo de acción de los fármacos utilizados para combatir sus síntomas se basa en la inhibición de la recaptación de neurotransmisores como la dopamina o la norepinefrina. Por otra parte, es sabido que el consumo de MDMA o éxtasis es...
Current Neuropharmacology
2021
Devahuti Chaliha, John C Mamo, Matthew A. Albrecht et al.
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, no gold-standard treatments exist to alleviate the core socio-behavioural impairments of ASD. Meanwhile, the prosocial empathogen/entactogen 3,4-methylene-dioxy-methamphetamine (MDMA) is known to enhance...
Liverpool John Moores University
2021
Stephen J. Smith
Twenty-two participants who identified as heterosexual, lesbian, gay, bisexual or transgendered clergy of the Church of England were recruited and interviewed using a semi-structured interview. The methodology employed incorporated Transpersonal Awareness with an Interpretative Phenomenological Analysis. After several levels of analysis the following superordinate themes emerged: (a) twenty of...
Acta Iuris Stetinensis
2021
Konrad Burdziak
Przedmiotem pracy uczyniono problematykę leczenia PTSD z wykorzystaniem MDMA jako sposobu przeciwdziałania zjawisku samobójstwa. Rozważania w tym zakresie przeprowadzono na tle polskiego prawa. W pracy wykorzystano metodę dogmatycznoprawną. Zdecydowano się przy tym skorzystać z derywacyjnej koncepcji wykładni prawa autorstwa M. Zielińskiego. Autor pracy ustalił, że: 1) PTSD może stanowić źródło...
European Journal of Psychotraumatology
2021
Lukas A Basedow, Sören Kuitunen-Paul, Melina Wiedmann et al.
15 citations
ABSTRACT Background: Adolescent patients with a substance use disorder (SUD) often fulfil the criteria for a co-occurring post-traumatic stress disorder (PTSD). However, it is not clear if these dual-diagnosed adolescents present with unique levels of substance use and how their substance use relates to PTSD symptom clusters. Objective: To investigate substance use in adolescents with...
Libro Comunicaciones
2021
1. Objetivos: MDMA (3,4-metilendioximetanfetamina), comúnmente conocida como “éxtasis”, es una droga habitualmente usada en ambiente lúdico. Sus efectos tóxicos a nivel del SNC son ampliamente conocidos, habiéndose demostrado particularmente el daño que se produce sobre el sistema serotoninérgico. Como consecuencia de esta toxicidad se ha reportado la aparición de psicopatología diversa, tanto...
Psychology and Behavioral Sciences
2021
Brenda Tichler
The importance of treating concurrent Post-Traumatic Stress Disorder (PTSD) and substance use with psychedelics is a controversial topic, hampered in part by a lack of empirical evidence and rigidity of substance scheduling. Traditional treatments for concurrent PTSD and substance use concerns are compartmentalized, with clinicians focusing on one condition over the other. In addition,...