The Journal of Sexual Medicine
May 1, 2023
Julie Suyama, Alexandra Dubinskaya, Karyn Eilber et al.
3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’ or ‘Molly’) is a synthetic psychostimulant and entactogenic drug of abuse that augments feelings of pleasure, increases energy, and distorts sensory perception. MDMA increases serotonin, dopamine, and norepinephrine neurotransmission within the mesolimbic reward pathway, which impacts human sexual function. While dopamine is implicated as a...
Physiology
May 1, 2023
Joshua Wyrosdic, Zahra Thirouin, Charles Bourque
Clinical studies have shown that hyponatremia can be induced by the ingestion of the recreational drug MDMA (3,4-Methylenedioxymethamphetamine, ecstasy) when combined with a water intake (Baggot et al., 2016). However, the mechanisms by which MDMA induces hyponatremia is unknown. Hyponatremia is a life-threatening condition that causes rapid swelling of the brain and is commonly encountered...
Psicología Conocimiento y Sociedad
May 1, 2023
Leticia Aszkinas Browarski, Juan Enrique Fernández
1 citation
Se presentan a continuación los resultados de un estudio exploratorio y descriptivo centrado en el análisis de los sentidos y vivencias asociados a experiencias de consumo de MDMA (3,4-metilendioximetanfetamina, Éxtasis) en usuarios jóvenes de esta sustancia que habitaban la ciudad de Montevideo en el período 2017-2019. Se desarrolló un muestreo no probabilístico en cadena que permitió la...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
May 1, 2023
Giulia Costa, Marcello Serra, Riccardo Maccioni et al.
13 citations
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)- 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) targets the nigrostriatal dopaminergic system in mice, inducing neurodegeneration and gliosis, causing acute hyperthermia and cognitive...
Psychotropes
April 21, 2023
Pierre Poloméni
Les adolescents et jeunes adultes participant à des événements musicaux consomment fréquemment des substances psychoactives pour améliorer la qualité des relations et des perceptions. Parmi ces substances, une association de LSD puis de MDMA, prises à une heure d’intervalle, dénommée Candy Flip, connue depuis longtemps, bénéficie d’une bonne réputation. Notre travail explore ces substances en...
European Journal of Pharmacology
April 15, 2023
Amal Aburahma, Srishti Rana, Ray A. Larsen et al.
5 citations
The increased use of the stimulant drug, 3,4-methylenedioxymethamphetamine (MDMA), more commonly known as Ecstasy, Molly or X, has been linked to the development of life-threatening hyperthermia in human and animal models. The current study aimed to investigate the role of the gut-adrenal axis in MDMA-induced hyperthermia by assessing the influence of the acute exogenous supplementation with...
Frontiers in Psychiatry
April 14, 2023
Jennifer L. Jones
4 citations
BackgroundAlcohol and other substance use disorders are commonly associated with post-traumatic stress disorder (PTSD), and the presence of these comorbidities is associated with worse treatment outcomes. Additionally, disparities in substance and PTSD prevalence have been associated with minority races and ethnicities, and minorities have been shown to be less likely to engage in treatment....
ACS Medicinal Chemistry Letters
April 13, 2023
Robert B. Kargbo
4 citations
This Patent Highlight describes derivatives of DMT, 5-MeO-DMT, and MDMA that are metabolically converted to biologically active analogs. When these prodrugs are administered to a subject, they potentially could be used therapeutically in conditions associated with neurological diseases. Furthermore, the disclosure provides methods to potentially treat conditions comprising major depressive...
Psychopharmacology
April 1, 2023
Keaton T Cameron-Burr, R Aaron Bola, Eugene A. Kiyatkin
5 citations
Hyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme cases. Current treatments such as whole-body cooling are only symptomatic and a clear need to develop pharmacological interventions exists. Dantrolene sodium, a peripheral muscle relaxant used in the treatment of malignant hyperthermia, has been proposed as...
Australian & New Zealand Journal of Psychiatry
April 1, 2023
Gillinder Bedi, Susan M Cotton, Alexandre A. Guerin et al.
17 citations
Recent years have seen escalating media, public and scientific interest in psychedelic medicine. Australia and New Zealand have been late to this research; however, in the past 2 years, rapid developments suggest that this is changing. Here, we argue for the need to critically review existing evidence in this field to guide future directions. We focus on...