Serotonergic psychedelics are being explored as therapeutic agents for mental health disorders and have also been shown to promote wakefulness. In a recently completed study (reported as preliminary findings), we showed that intravenous administration of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a classic serotonergic psychedelic, can induce wakefulness and reverse the state of anesthesia produced...
Pain induction results in the initiation of neuroinflammatory and neurodegenerative processes, leading to neuromodulation, while conventional analgesic treatments frequently entail undesirable side effects. This research delves into the potent and selective analgesic attributes of Iboga derivatives in the context of acute and chronic pain models. Specifically, the study explores the effcacy of...
Psychedelics, including N, N, Dimethyltryptamine (DMT), are being increasingly explored for therapeutic potential to treat psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder. These and other psychiatric conditions have a bidirectional relationship with sleep patterns but the impact of psychedelics, particularly DMT, on sleep architecture is incompletely...
PhysiologyMay 1, 2024Julianna Cruz, Matias Zanuzzi, Jinhee Jeong et al.
Introduction: Chronic Kidney Disease (CKD) is associated with increased cardiovascular disease risk in part due to endothelial dysfunction. Studies have suggested that mindfulness-based stress reduction (MBSR) may have beneficial physiologic effects on cardiovascular disease risk; however, the potential beneficial effects of MBSR on endothelial function in CKD are unknown. We tested the...
PhysiologyMay 1, 2024Jinhee Jeong, Matias Zanuzzi, Dana DaCosta et al.
Intro: Chronic kidney disease (CKD) is characterized by chronic overactivation of the sympathetic nervous system (SNS) that leads to increased blood pressure and cardiovascular disease risk. Mindfulness-Based Stress Reduction (MBSR) is an 8-week mindfulness meditation training program that has previously been shown to reduce blood pressure and improve autonomic balance in healthy and some...
PhysiologyMay 1, 2023Joshua Wyrosdic, Zahra Thirouin, Charles Bourque
Clinical studies have shown that hyponatremia can be induced by the ingestion of the recreational drug MDMA (3,4-Methylenedioxymethamphetamine, ecstasy) when combined with a water intake (Baggot et al., 2016). However, the mechanisms by which MDMA induces hyponatremia is unknown. Hyponatremia is a life-threatening condition that causes rapid swelling of the brain and is commonly encountered...
PhysiologyMay 1, 2023Grant Thivierge, Aditi Vyas, Brigitte Morin et al.
Mindfulness-based stress reduction (MBSR) has been shown to reduce blood pressure and anxiety in several studies, but the effects of MBSR on arterial stiffness and muscle sympathetic nerve activity (MSNA) have not been studied. We hypothesized that MBSR would lower arterial stiffness and MSNA. The present study randomized 22 adults (17 male; 5 female; age 25±1 years; BMI 26±1 kg/m2) with...