Psychopharmacology
April 1, 2023
Keaton T Cameron-Burr, R Aaron Bola, Eugene A. Kiyatkin
5 citations
Hyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme cases. Current treatments such as whole-body cooling are only symptomatic and a clear need to develop pharmacological interventions exists. Dantrolene sodium, a peripheral muscle relaxant used in the treatment of malignant hyperthermia, has been proposed as...
Handbook of clinical neurology
2018
Eugene A. Kiyatkin
Brain temperature is a physiologic parameter that depends on metabolism-related intracerebral heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. Despite the importance of temperature as a metabolism-related parameter and a factor affecting neural activity and function, it is generally believed that brain temperature is a tightly...
Current Topics in Behavioral Neurosciences
2017
Eugene A. Kiyatkin, Suelynn E Ren
Psychomotor stimulants are frequently used by humans to intensify the subjective experience of different types of social interactions. Since psychomotor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug...
Neuropsychopharmacology
January 2016
Eugene A. Kiyatkin, Suelynn E Ren, Ken T. Wakabayashi et al.
MDMA-induced hyperthermia is highly variable, unpredictable, and greatly potentiated by the social and environmental conditions of recreational drug use. Current strategies to treat pathological MDMA-induced hyperthermia in humans are palliative and marginally effective, and there are no specific pharmacological treatments to counteract this potentially life-threatening condition. Here, we...
Journal of Neuroscience
June 4, 2014
Eugene A. Kiyatkin, A. H. Kim, Ken T. Wakabayashi et al.
47 citations
MDMA (Ecstasy) is an illicit drug used by young adults at hot, crowed "rave" parties, yet the data on potential health hazards of its abuse remain controversial. Here, we examined the effect of MDMA on temperature homeostasis in male rats under standard laboratory conditions and under conditions that simulate drug use in humans. We chronically implanted thermocouple microsensors in the nucleus...
Brain Research
September 4, 2008
Michael S Smirnov, Eugene A. Kiyatkin
Marijuana smoking dramatically alters responses to various environmental stimuli. To study this phenomenon, we assessed how delta-9-tetrahydrocannabinol (THC), a primary psychoactive ingredient of marijuana, affects locomotor and brain (nucleus accumbens or NAcc), muscle and skin temperature responses to natural arousing stimuli (one-minute tail-pinch and one-minute social interaction with...
European Journal of Neuroscience
July 1, 2004
Paul Brown, Eugene A. Kiyatkin
105 citations
Abstract Drugs of abuse, such as 3,4‐methylenedioxymethamphetamine (MDMA), often have more powerful effects during states of increased activation and under specific environmental conditions. Because hyperthermia is a major complication of MDMA use and a factor potentiating neurotoxicity, we examined the effects of this drug (9 mg/kg, sc; approximately one‐fifth of the known LD 50 in rats) on...