MDMA: all studies (page 163) - The Consciousness Library

A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response.

European Journal of Pharmacology October 1, 2004 Alfred Richard Green, Esther O'Shea, María Isabel Colado

The predominant severe acute adverse effect following ingestion of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) by recreational users is hyperthermia which can induce other associated clinical problems and occasionally death. There is no pharmacologically specific treatment. MDMA also induces dose-dependent hyperthermia in experimental animals. This review examines the consequences of MDMA...

DOI: 10.1016/j.ejphar.2004.07.006 Full text

Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.

Journal of Pharmacology and Experimental Therapeutics October 2004 Douglas C. Jones, Serrine S. Lau, Terrence J. Monks

3,4-Methylenedioxyamphetamine (MDA) and 3,4-methyl-enedioxymethamphetamine (MDMA, ecstasy) are widely abused amphetamine derivatives that target the serotonin system. The serotonergic neurotoxicity of MDA and MDMA seems dependent on their systemic metabolism. 5-(Glutathion-S-yl)-alpha-methyldopamine [5-(GSyl)-alpha-MeDA] and 2,5-bis(glutathion-S-yl)-alpha-methyldopamine...

DOI: 10.1124/jpet.104.069260 Full text

Differential Response of nNOS Knockout Mice to MDMA (“Ecstasy”)‐ and Methamphetamine‐Induced Psychomotor Sensitization and Neurotoxicity

Annals of the New York Academy of Sciences October 1, 2004 Yossef Itzhak, Karen L. Anderson, Syed F. Ali 31 citations

A bstract : It has been shown that mice deficient in neuronal nitric oxide synthase (nNOS) gene are resistant to cocaine‐induced psychomotor sensitization and methamphetamine (METH)‐induced dopaminergic neurotoxicity. The present study was undertaken to investigate the hypothesis that nNOS has a major role in dopamine (DA)‐ but not serotonin (5‐hydroxytryptamine; 5‐HT)‐mediated effects of...

DOI: 10.1196/annals.1316.015 MDMA Ecstasy Sensitization Methamphetamine +4

Potentiation of (DL)‐3,4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939

Neuroscience Research Communications September 1, 2004 Brian D. Armstrong, Elena Paik, Seririthanar Chhith et al.

AbstractTo elucidate the role of the serotonin (5‐HT)2A/2C receptors in 3,4‐methylenedioxymethamphetamine (MDMA)‐induced neurotoxicity, MDMA was administered to rats and the presence of the serotonin transporter (5‐HTT) was assessed at the protein level with immunohistochemistry (IHC), and the RNA level with a Northern blotting technique. d‐lysergic acid diethylamide (LSD) and MDL 11,939 were...

DOI: 10.1002/nrc.20023

Impaired executive function in male MDMA ("ecstasy") users.

Psychopharmacology September 2004 Niels Alting Von Geusau, Pieter Stalenhoef, Mariette Huizinga et al.

Long-term users of ecstasy have shown impaired performance on a multitude of cognitive abilities (most notably memory, attention, executive function). Research into the pattern of MDMA effects on executive functions remains fragmented, however. To determine more systematically what aspects of executive function are affected by a history of MDMA use, by using a model that divides executive...

DOI: 10.1007/s00213-004-1832-8 Full text

Effect of Repeated (‘Binge’) Dosing of MDMA to Rats Housed at Normal and High Temperature on Neurotoxicdamage to Cerebral 5-Ht and Dopamine Neurones

Journal of Psychopharmacology September 1, 2004 Verónica Sánchez, Esther O’shea, Kathryn S. Saadat et al. 66 citations

The technique of ‘binge’ dosing (several doses in one session) by recreational users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) requires evaluation in terms of its consequences on the acute hyperthermic response and long-term neurotoxicity. We examined the neurotoxic effects of this dosing schedule on 5-HT and dopamineneurones in the rat brain. When repeated (three) doses of MDMA (2,...

DOI: 10.1177/026988110401800312 MDMA Ecstasy Serotonin Dopamine +8

Use of MDA (The "Love Drug") and Methamphetamine in Toronto by Unsuspecting Users of Ecstasy (MDMA)

Journal of Forensic Sciences September 1, 2004 Kathryn S. Kalasinsky, J. Hugel, Sj Kish 42 citations

Abstract It has recently been reported that purity of illicit tablets of ecstasy (MDMA) is now high. Our objective was to confirm whether hair of drug users, who request only ecstasy from their supplier, contains MDMA in the absence of other drugs. GC-MS analysis of scalp hair segments disclosed the presence of MDMA in 19 of 21 subjects and amphetamine/methamphetamine in eight subjects....

DOI: 10.1520/jfs2003401 Ecstasy MDMA Methamphetamine Medical examiner +7

3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B.

Neuroscience Letters August 26, 2004 Sandra L Hrometz, Andrew Brown, David E Nichols et al.

3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has been shown to induce long-term deficits in serotonergic function in animal models. Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors...

DOI: 10.1016/j.neulet.2004.05.075 Full text

Residual neuropsychological effects of illicit 3,4-methylenedioxymethamphetamine (MDMA) in individuals with minimal exposure to other drugs.

Drug and Alcohol Dependence August 16, 2004 John H. Halpern, Harrison G. Pope, Andrea R Sherwood et al.

A substantial literature suggests that users of illicit 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") display residual cognitive deficits. Most MDMA users, however, use other illicit drugs as well, so it is difficult to be certain that these deficits are due to MDMA, as opposed to other drug use or additional confounding factors. We administered a battery of neuropsychological tests to...

DOI: 10.1016/j.drugalcdep.2004.02.008 Full text

Exposure to 3,4‐methylenedioxymethamphetamine (MDMA) on postnatal days 11–20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning

International Journal of Developmental Neuroscience August 1, 2004 Charles V. Vorhees, Tracy M. Reed, Matthew R. Skelton et al. 76 citations

Abstract 3,4‐Methylenedioxymethamphetamine (MDMA) in previous experiments has been shown to induce long‐term spatial and sequential learning and memory deficits in adult offspring after exposure to the drug on postnatal (P) days 11–20, but not after exposure on P1–10. Herein we further tested for the effects of MDMA (0, 5, 10 or 20 mg/kg × 2/day) after exposure on P11–20 on reference and...

DOI: 10.1016/j.ijdevneu.2004.06.003 MDMA Working memory Memory impairment Water maze +2