Research published in International Journal of Developmental Neuroscience

Lutein Exerts Antioxidant and Neuroprotective Role on Schizophrenia-Like Behaviours in Mice.

International Journal of Developmental Neuroscience February 1, 2025 Helia Aziziha, Shahin Hassanpour, Morteza Zendehdel 2 citations

Schizophrenia is an esteemed neuropsychiatric condition delineated by the manifestation which role of the N-methyl-D-aspartate receptor (NMDAR) is important. Lutein administration exhibits protective effects via NMDA receptors. Thus, the main goal of this research was to investigate how lutein can possibly act as an antioxidant and provide protection for the brain against schizophrenia-like...

DOI: 10.1002/jdn.10407 Full text Ketamine Lutein Mice Schizophrenia‐like behaviours +4

Early emergence of altered 5-HT2A receptor-evoked behavior, neural activation and gene expression following maternal separation.

International Journal of Developmental Neuroscience April 2018 Ankit Sood, Sthitapranjya Pati, Amrita Bhattacharya et al.

The early stress of Maternal Separation (MS) contributes to the establishment of adult psychopathology. The serotonergic (5-HT) system is implicated during this temporal window in mediating the development of mood-related behaviors. MS is reported to evoke altered 5-HT2A receptor function in adulthood. However, the ontogeny of altered 5-HT2A receptor responsivity following MS remains unknown....

DOI: 10.1016/j.ijdevneu.2017.10.005 Full text Serotonin Early stress Head twitch behavior Immediate early gene +2

Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia.

International Journal of Developmental Neuroscience May 2011 F Liu, X Zou, N Sadovova et al.

Repeated administration of phencyclidine (PCP), an N-methyl-d-aspartate (NMDA) receptor antagonist, during development, may result in neuronal damage that leads to behavioral deficits in adulthood. The present study examined the potential neurotoxic effects of PCP exposure (10mg/kg) in rats on postnatal days (PNDs) 7, 9 and 11 and the possible underlying mechanism(s) for neurotoxicity. Brain...

DOI: 10.1016/j.ijdevneu.2010.07.234 Full text

Exposure to 3,4‐methylenedioxymethamphetamine (MDMA) on postnatal days 11–20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning

International Journal of Developmental Neuroscience August 1, 2004 Charles V. Vorhees, Tracy M. Reed, Matthew R. Skelton et al. 76 citations

Abstract 3,4‐Methylenedioxymethamphetamine (MDMA) in previous experiments has been shown to induce long‐term spatial and sequential learning and memory deficits in adult offspring after exposure to the drug on postnatal (P) days 11–20, but not after exposure on P1–10. Herein we further tested for the effects of MDMA (0, 5, 10 or 20 mg/kg × 2/day) after exposure on P11–20 on reference and...

DOI: 10.1016/j.ijdevneu.2004.06.003 MDMA Working memory Memory impairment Water maze +2

Neurotoxic effects of MDMA (“ecstasy”) administration to neonatal rats

International Journal of Developmental Neuroscience June 5, 2004 Jerrold S. Meyer, Mark Grande, Kenneth M Johnson et al. 50 citations

Abstract 3,4‐Methylenedioxymethamphetamine damages fine serotonergic fibers and nerve terminals in adult organisms. Developing animals seem to be less susceptible to this effect, possibly due to a lack of drug‐induced hyperthermia. We tested this hypothesis by producing hyperthermia in neonatal rats for 2 h after each of twice‐daily MDMA (10 mg/kg s.c.) or saline injections administered from...

DOI: 10.1016/j.ijdevneu.2004.04.007 MDMA Serotonergic Forebrain Endocrinology +4

Gestational exposure to phencyclidine (PCP) in rats decreases PCP binding sites in term fetal brain

International Journal of Developmental Neuroscience 1988 S. F. Ali, G. Ahmad, W. Slikker et al.

AbstractPregnant Sprague‐Dawley rats were treated with 5 mg/kg body weight of phencyclidine (PCP) injected at 1 ml/kg subcutaneously on three consecutive days at four different stages of gestation. Within 10–30 min after treatment, dams showed some lack of motor coordination and became lethargic. On gestational day 21, all rats were killed by decapitation and brains were dissected and stored...

DOI: 10.1016/0736-5748(88)90062-7