Mechanism of 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy)‐mediated mitochondrial dysfunction in rat liver
PROTEOMICS September 1, 2008 Kwan–hoon Moon, Vijay Upreti, Li‐rong Yu et al. 62 citations
Abstract Despite numerous reports citing the acute hepatotoxicity caused by 3,4‐methylenedioxymethamphetamine (MDMA) (ecstasy), the underlying mechanism of organ damage is poorly understood. We hypothesized that key mitochondrial proteins are oxidatively modified and inactivated in MDMA‐exposed tissues. The aim of this study was to identify and investigate the mechanism of inactivation of...