PROTEOMICS
January 2011
Vijay Upreti, Kwan–hoon Moon, Li‐rong Yu et al.
It is well established that 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) causes acute liver damage in animals and humans. The aim of this study was to identify and characterize oxidative modification and inactivation of cytosolic proteins in MDMA-exposed rats. Markedly increased levels of oxidized and nitrated cytosolic proteins were detected 12 h after the second administration of two...
Current Pharmaceutical Biotechnology
June 27, 2010
Byoung‐joon Song, Kwan–hoon Moon, Vijay Upreti et al.
73 citations
Despite numerous reports about the acute and sub-chronic toxicities caused by MDMA (3,4-methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is poorly understood. The aim of this review is to present an update of the mechanistic studies on MDMA-mediated organ damage partly caused by increased oxidative/nitrosative stress. Because of the extensive reviews on...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
June 1, 2009
Zeynep S Teksin, Insong J. Lee, Noble N Nemieboka et al.
76 citations
Salvinorin A is an unregulated potent hallucinogen isolated from the leaves of Salvia divinorum. It is the only known non-nitrogenous kappa-opioid selective agonist, and rivals synthetic lysergic acid diethylamide (LSD) in potency. The objective of this study was to characterize the in vitro transport, in vitro metabolism, and pharmacokinetic properties of Salvinorin A. The transport...
PROTEOMICS
September 1, 2008
Kwan–hoon Moon, Vijay Upreti, Li‐rong Yu et al.
62 citations
Abstract Despite numerous reports citing the acute hepatotoxicity caused by 3,4‐methylenedioxymethamphetamine (MDMA) (ecstasy), the underlying mechanism of organ damage is poorly understood. We hypothesized that key mitochondrial proteins are oxidatively modified and inactivated in MDMA‐exposed tissues. The aim of this study was to identify and investigate the mechanism of inactivation of...
Journal of Pharmaceutical Sciences
April 2008
Vijay Upreti, Natalie D. Eddington
Fluoxetine has been shown to provide protection from MDMA induced long term neurotoxicity. The purpose of this investigation is to evaluate the pharmacokinetic drug interaction between MDMA and fluoxetine and also to determine the role of P-glycoprotein (P-gp) on mediating drug-drug interactions with MDMA. Bi-directional transport studies were conducted across MDCK-MDR1 and Caco-2 monolayers....