Are Females More Sensitive to MDMA-Related Discriminative Stimuli?
The Open Addiction Journal March 29, 2011 DOI: 10.2174/1874941001104010010 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male and female rats |
| Interventions | Carbetocin Atosiban MDMA |
| Topics | MDMA |
| Citations | 1 |
| Key findings | Oxytocin receptor activation contributes to the interoceptive cues of MDMA in rats, as shown by the effects of the agonist carbetocin and antagonist atosiban in a drug discrimination paradigm. |
Abstract
are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist carbetocin [3] and antagonist atosiban [4], were utilised in a 3-way drug discrimination paradigm [5].
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 2
- A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (±)-MDMA in rats. Experimental and Clinical Psychopharmacology 2000
- Are there sex differences associated with the effects of ecstasy/3,4-methylenedioxymethamphetamine (MDMA)? Neuroscience and biobehavioral reviews 2007