3,4-Methylenedioxymethamphetamine (MDMA) Induced Hyperthermia-The Role of Pro-Inflammatory Cytokines
The Open Addiction Journal March 29, 2011 DOI: 10.2174/1874941001104010048 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Minocycline |
| Duration | Up to three days pretreatment |
| Topics | MDMA |
| Citations | 1 |
| Key findings | Pretreatment with minocycline significantly reduces the severity of MDMA-induced hyperthermia in rats, and this effect is time-dependent, requiring up to three days of pretreatment for maximum effect. |
Abstract
Project Background The main MDMA-induced adverse effect is disruption of normal thermoregulation leading to life threatening hyperthermia which is exacerbated by high ambient temperature and linked to chronic neurotoxicity. Although the focus of the majority of research on MDMAinduced loss of thermoregulation has been on brain serotonergic and dopaminergic systems, results obtained from our recent studies suggest an association between microglial activation and MDMA-induced hyperthermia. We have demonstrated that pretreatment with minocycline, an antibiotic with glial attenuating properties, can significantly reduce the severity of MDMA-induced hyperthermia in rats. We have also demonstrated that minocycline’s ability to inhibit MDMA induced hyperthermia is time-dependent process and you need up to three days pre-treatment with minocycline to achieve maximum effects.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 3
- Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat Journal of Neuroscience July 1, 1998
- A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons. Neurotoxicity Research August 2010
- A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response. European Journal of Pharmacology October 1, 2004