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Thaís S. Yokoyama

4 papers in the library · 124 citations · publishing 2015-2023

Papers

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Prepulse inhibition of the acoustic startle reflex impairment by 5-HT2A receptor activation in the inferior colliculus is prevented by GABAA receptor blockade in the pedunculopontine tegmental nucleus.

Behavioural Brain Research June 25, 2023 Rodolpho Pereira de Oliveira, Thaís S. Yokoyama, Lucas de Santana Cardoso Thomaz et al. 2 citations

The relationship between serotonin dysfunction and schizophrenia commenced with the discovery of the effects of lysergic acid diethylamide (LSD) that has high affinity for 5-HT2A receptors. Activation of these receptors produces perceptual and behavioural changes such as illusions, visual hallucinations and locomotor hyperactivity. Using prepulse inhibition (PPI) of the acoustic startle, which...

DOI: 10.1016/j.bbr.2023.114436 (opens in new tab) Full text (opens in new tab) Gaba Inferior colliculus Pedunculopontine tegmental nucleus Prepulse inhibition +5

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice.

Frontiers in Pharmacology 2021 Gabrielle M Henriques, Alexia Anjos-Santos, Isa R S Rodrigues et al. 10 citations

Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders. In animal models, ibogaine reduces ethanol self-administration. However, no study to date has investigated the effects of ibogaine on ethanol-induced conditioned place preference (CPP). The present study aimed...

DOI: 10.3389/fphar.2021.739012 (opens in new tab) Full text (opens in new tab) Conditioned place preference Ethanol Mice Reinstatement +3

Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations

Psychopharmacology July 16, 2020 Henrique Sousa Reis, Isa R S Rodrigues, Alexia Anjos-Santos et al. 21 citations

RationaleAccumulating evidence suggests that ayahuasca, a hallucinogenic beverage used in traditional Amazonian communities for ritualistic and curative purposes, has been associated with reduced rates of substance use disorders. However, the brain mechanisms underlying the therapeutic effects of ayahuasca have not yet been fully elucidated.ObjectivesThe aim of the present study was to...

DOI: 10.1007/s00213-020-05609-6 (opens in new tab) Ayahuasca Methylphenidate Infralimbic cortex Ventral tegmental area +7

Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice

Physiology & Behavior January 28, 2015 Alexandre J. Oliveira-Lima, Renato Antunes Dos Santos, A.w. Hollais et al. 91 citations

BackgroundHallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments in the study of hallucinogens led to a renewal of interest regarding the application of these drugs in the treatment of addiction. In this scenario, accumulating evidence suggests that the hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems.MethodsWe...

DOI: 10.1016/j.physbeh.2015.01.032 (opens in new tab) Addiction Ayahuasca Behavioral sensitization Hallucinogen +1