Science
January 19, 2024
Alexis Turner
A pair of anthropologists’ personal papers shed light on US psychedelic science in the mid-20th century
2024
Frank P. Petersen
Dale gefragt wurde, wer die Isolierung des wasserlöslichen, mysteriösen Wirkstoffs aus den Keulenkopf-Sklerotien angehen könne, dachte er gleich an seinen langjährigen Kollegen und Chefchemiker Harold Ward Dudley (1887–1935) am National Institute for Medical Research. Er kannte ihn bestens von gemeinsamen Forschungsarbeiten zu Histamin, Acetylcholin und Insulin, bei denen Dudley harte Nüsse zu...
Journal of Psychoactive Drugs
2024
Kelan Thomas, Robert L. Jesse, Nicky J. Mehtani et al.
4 citations
In recent years, policymakers have proposed and implemented regulatory changes promoting the deprioritization, decriminalization, or state-level legalization of one or more psychedelic substances, usually referencing data from clinical trials as reasons to support liberalizing drug control policies. As psychedelic policies continue to be drafted, personal possession limits may be considered for...
Naunyn-Schmiedeberg's Archives of Pharmacology
2024
Ulrich Gergs, Hannes Jacob, Pauline Braekow et al.
16 citations
Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice with cardiomyocyte-specific...
British Journal of Clinical Pharmacology
2024
Friederike Holze, Livio Erne, Urs Duthaler et al.
12 citations
Lysergic acid diethylamide (LSD) is currently investigated for several neurological and psychiatric illnesses. Various studies have investigated the pharmacokinetics and the pharmacokinetic-pharmacodynamic relationship of LSD in healthy participants, but data on urinary recovery and confirmatory studies are missing. The present study characterized the pharmacokinetics,...
JAMA Psychiatry
2024
Claire A Walsh, Lauren Gorfinkel, Dvora Shmulewitz et al.
24 citations
Renewed interest in the clinical potential of hallucinogens may lead people with depression to a generally more positive view of the use of lysergic acid diethylamide (LSD). Therefore, past-year LSD use among people with depression may be increasing in prevalence. To assess time trends in the prevalence of past-year nonmedical LSD use by past-year major depression status and the variation in...
Substance Use & Misuse
2024
Benjamin A. Korman
4 citations
Although studies have demonstrated that the use of lysergic acid diethylamide (LSD) is on the rise in the United States, it remains unclear how this trend looks across the hierarchical ladder of the American workforce. This is relevant given that LSD is increasingly being touted as a means of boosting creativity and performance, with mounting anecdotal evidence that business managers in...
Journal of Psychopharmacology
2024
Otto Simonsson, Peter S. Hendricks, Cecilia Ud Stenfors et al.
Whereas findings from case reports and cross-sectional studies suggest that naturalistic psychedelic use may be associated with unusual visual experiences that occur after the acute pharmacological effects have subsided, such findings need to be replicated in longitudinal studies to better understand potential cause-and-effect relationships. To investigate longitudinal associations between...
Brain Communications
2024
Ashley Ghaw, Alisha Chunduri, Arnold Chang et al.
13 citations
Lysergic acid diethylamide is a hallucinogen with complex neurobiological and behavioural effects. This is the first study to use MRI to follow functional changes in brain activity in response to different doses of lysergic acid diethylamide in fully awake, drug-naive rats. We hypothesized that lysergic acid diethylamide would show a dose-dependent increase in activity in the prefrontal cortex...
PLoS One
2024
Benjamin A. Korman
Recent studies on classic psychedelics have suggested that their use is associated with psychological strengths and resilience, thereby conferring users a type of psychological protection relative to non-users. However, this idea has been brought into question by recent findings suggesting that lifetime users of lysergic acid diethylamide (LSD) report worse mental health during stressful...
Revue de l'infirmiere
2024
Caroline Amberger, Laurent Szczesniak
In this article, we aim to highlight the specific role of nurses in the interdisciplinary model of psychedelic-assisted psychotherapy. We argue that the plural competencies of our profession are at the heart of future issues in psychiatry and the use of psychedelics.