AIDS and behaviorJune 9, 2025Chiara Fusetti, Enrico Caruso, Andrea Giacomelli et al.2 citations
Chemsex, the use of psychostimulant substances during sexual activity particularly among men who have sex with men (MSM), is a growing public health concern. This study aimed to assess drug use, engagement in chemsex, and related knowledge among pre-exposure prophylaxis (PrEP) users and people with HIV (PWH) attending two sexually transmitted infection (STI) services in Milan, Italy. An...
Neurological and psychiatric disorders are considered one of the major problems of today's societies and cause many individual and social problems. Current treatments are effective, but due to their burdens, there is always an effort to introduce novel treatments. Psychedelics, a diverse group of psychoactive compounds, including LSD, psilocybin, DMT, MDMA, and ketamine, have shown potential in...
Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases. Olanzapine-fluoxetine combination, rTMS, Intravenous ketamine and Electroconvulsive therapy have been till now studied in TRD. Dextromethorphan-bupropion is a newer...
Despite the fact that drugs of abuse are illegal, a drug-free festival still remains an utopia in most settings. For law enforcement purposes, it is necessary to rapidly determine whether controlled substances are involved. On-site testing is a challenging task because drugs appear in different physical forms and concentrations. The aim of this study was to compare the performance of two...
Toxicology ReportsJune 1, 2025Leonardo Costalonga Rodrigues, Alexandre Barcia de Godoi, Viviane Cristina Fais et al.4 citations
New psychoactive substances (NPS) have emerged as a significant public health concern, with synthetic cannabinoid receptor agonists (SCRAs) and ketamine derivatives being among the most frequently detected compounds in the forensic context worldwide. The Fish Embryo Acute Toxicity (FET) and Maximum Tolerated Concentration (MTC) tests are used to evaluate the acute toxicity of chemicals. In this...
We present a neural mass model (NMM) of the brain thalamo-cortico-thalamic (TCT) network to understand the effectiveness of non-invasive treatment with transcranial Direct Current Stimulation (tDCS) in reversing the anomalous electroencephalogram (EEG) oscillations in Schizophrenia. Our TCT NMM consists of twelve neural populations representing the thalamus and cortex modules of the visual...
The 2020 American Burn Association guidelines recommend a multimodal approach to pain management comprised of both opioids and non-opioids. The purpose of this study was to compare outcomes before and after implementation of a multimodal pain order set in the burn admission order set within the electronic medical record. This single center, retrospective, cohort study was conducted at an...
N-methyl-D-aspartate receptors (NMDA receptors) play a crucial role as ionotropic glutamate receptors in regulating neuroplasticity, learning, memory, and a range of psychiatric disorders. Studies indicate that dysfunction of NMDA receptors is a key pathological mechanism in depression, where abnormal activation can result in neuronal excitotoxicity, excessive extracellular calcium ion...
This study aimed to evaluate the level of pain caused by routine procedures during cardiac catheterization and explore ways to enhance patient comfort during the procedure based on the findings. The study involved 24 pediatric patients with congenital heart disease who underwent cardiac catheterization at our center. Pain perception was assessed using skin conductance activity, a non-invasive...
Objectives During anesthesia induction, fluctuations in systemic hemodynamic may also alter cerebral hemodynamic, especially in patients with intracranial tumors, as these patients might have impaired cerebral autoregulation. This study compared the effects of ketofol (a mixture of ketamine and propofol) and etomidate on cerebral blood flow, oxygenation, and systemic hemodynamics during...