We present a neural mass model (NMM) of the brain thalamo-cortico-thalamic (TCT) network to understand the effectiveness of non-invasive treatment with transcranial Direct Current Stimulation (tDCS) in reversing the anomalous electroencephalogram (EEG) oscillations in Schizophrenia. Our TCT NMM consists of twelve neural populations representing the thalamus and cortex modules of the visual...
The 2020 American Burn Association guidelines recommend a multimodal approach to pain management comprised of both opioids and non-opioids. The purpose of this study was to compare outcomes before and after implementation of a multimodal pain order set in the burn admission order set within the electronic medical record. This single center, retrospective, cohort study was conducted at an...
N-methyl-D-aspartate receptors (NMDA receptors) play a crucial role as ionotropic glutamate receptors in regulating neuroplasticity, learning, memory, and a range of psychiatric disorders. Studies indicate that dysfunction of NMDA receptors is a key pathological mechanism in depression, where abnormal activation can result in neuronal excitotoxicity, excessive extracellular calcium ion...
This study aimed to evaluate the level of pain caused by routine procedures during cardiac catheterization and explore ways to enhance patient comfort during the procedure based on the findings. The study involved 24 pediatric patients with congenital heart disease who underwent cardiac catheterization at our center. Pain perception was assessed using skin conductance activity, a non-invasive...
Objectives During anesthesia induction, fluctuations in systemic hemodynamic may also alter cerebral hemodynamic, especially in patients with intracranial tumors, as these patients might have impaired cerebral autoregulation. This study compared the effects of ketofol (a mixture of ketamine and propofol) and etomidate on cerebral blood flow, oxygenation, and systemic hemodynamics during...
Current evidence remains insufficient to support the use of psychedelics for substance use disorders in routine clinical practice. Psilocybin has the most supportive data for alcohol use disorder, though it is of moderate quality. The evidence quality is generally low, with significant risk of bias due to poor blinding. Only half of identified studies were RCTs, with 44% conducted over 50 years...
Psychedelics may be promising treatments for substance use disorders (SUD). This study aims to understand how individuals with alcohol use disorder (AUD), opioid use disorder (OUD), and psychiatric disorders perceive and experience psychedelics for both nonmedical and medical use. Data for this cross-sectional survey study were collected from June 2023 to February 2024 at a large, tertiary...
medRxivMay 27, 2025Colin G Walsh, Michael Ripperger, Thomas H McCoy et al.
preprint
As multiple strategies have emerged for managing treatment-resistant major depressive disorder, efficient identification of individuals at elevated risk for this outcome earlier in their illness course remains essential. We extracted electronic health records data for all individuals with a diagnosis of major depressive disorder who received an index antidepressant prescription in the clinical...
My findings show, for the first time, what causes loss of awareness, anesthesia, memory replay, opioids induced respiratory depression (OIRD), and slow wave sleep. Opiates are fast pain relievers and anesthetics that can cause respiratory arrest. I found how mu-opioids and other medial habenula activators slowdown respiration during SWS and anesthesia. Using DTI method I observed that human...
Over the past years, a number of clinical and preclinical investigations have been documented, suggesting treatment strategies and pharmaceuticals for neuropathic pain and depressive disorders, potentially beneficial in cases where these conditions are comorbid. This review lists these potential treatment options and discusses the proposed underlying mechanisms of action and their limitations,...