Toxicology ReportsAugust 4, 2026Anila Jaleel, Mahnoor Khan, Kiran Namoos et al.
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a widely abused recreational drug associated with multi-organ toxicity. Objective was to compare hepatic, renal, and systemic biochemical abnormalities after acute MDMA exposure alone and with alcohol. This cross-sectional pilot study was conducted at Sheikh Zayed bin Al Nahyan and Shalamar Medical and Dental Colleges, Pakistan. The study...
Toxicology ReportsMay 10, 2026Amadea Bleisch, Selina Späni, Regina Schumann et al.
Introduction: Nutmeg is a widely used culinary spice. When ingested in large quantities it has psychoactive and hallucinogenic effects. Case reports: We present the case of a 23-year-old man on long-term fluoxetine and quetiapine who ingested 75 g of nutmeg with suicidal intent. Four hours later, he presented himself to the emergency department of the nearest hospital with tachycardia and...
Toxicology ReportsJune 1, 2025Sabrina Marongiu, Maarten van Eijk, Femke M J Gresnigt et al.9 citations
The recreational use of ketamine has risen significantly in the Netherlands, particularly among young adults in nightlife settings. This trend has been accompanied by an increase in first aid incidents involving ketamine, often in combination with other substances such as alcohol or MDMA, leading to heightened toxicity. Acute intoxication with ketamine manifests through symptoms like agitation,...
Toxicology ReportsJune 1, 2025Leonardo Costalonga Rodrigues, Alexandre Barcia de Godoi, Viviane Cristina Fais et al.4 citations
New psychoactive substances (NPS) have emerged as a significant public health concern, with synthetic cannabinoid receptor agonists (SCRAs) and ketamine derivatives being among the most frequently detected compounds in the forensic context worldwide. The Fish Embryo Acute Toxicity (FET) and Maximum Tolerated Concentration (MTC) tests are used to evaluate the acute toxicity of chemicals. In this...
Drug use represents a prevalent and multifaceted societal problem, with profound implications for public health, social welfare, and economic stability. To circumvent strict international drug control regulations, there is a growing trend in the development and market introduction of novel psychoactive substances (NPS), encompassing a wide range of compounds with psychoactive properties. This...
Toxicology ReportsJune 1, 2025Aliaa A Hodeib, Alshaimma Mahmoud Elmansy, Mona M Ghonem2 citations
Acute cannabinoids toxicity is an alarming toxicological problem. The current study aimed to compare children and adults with acute natural cannabinoids toxicity and highlight cases with acute synthetic cannabinoids (SCs) toxicity. This retrospective cross-sectional study was conducted on patients with acute cannabinoids toxicity admitted to Tanta University Poison Control Center from January...
Toxicology ReportsDecember 19, 2024Elizabeth F. Ebbens, Saralyn R. Williams, Rebecca E. Bruccoleri et al.
Medicinal mushrooms are widely available as health supplements, and the federal government does not currently require these products to be examined for quality and contents. This places consumers at risk for unintentional ingestion of other substances, including toxic mushroom species. We describe a case report of an ingestion of an edible medicinal mushroom product likely contaminated with...
The NBOMe (N-2-methoxybenzyl-phenethylamines) family of compounds are synthetic hallucinogens derived from the 2C series. Although this family of compounds has been responsible for multiple cases of acute toxicity and several deaths around the world, to date there are few studies. These compounds act as potent 5-HT2A receptor agonists, including the hallucinogen 25C-NBOMe...
The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. MDMA treatment of rats during a period of brain growth analogous to late human gestation leads to neurochemical and behavioral changes. MDMA from postnatal day (P)11–20 in rats produces reductions in serotonin and deficits in spatial and route-based navigation. In this experiment we examined the impact of MDMA...