March 13, 2024
Susan Blackmore, Emily T. Troscianko
46 citations
Altered states of consciousness (ASCs) are surprisingly hard to define and to measure. Neither ‘subjective’ methods (like verbal reports) nor ‘objective’ measures (such as how the state is induced, or physiological and behavioural criteria) are entirely satisfactory. Attempts to map ASCs are reviewed, including two- or three-dimensional maps such as Tart&s;s and Laureys’, and Hobson&s;s AIM...
Cahiers francophones de soins palliatifs
February 14, 2024
Houman Farzin
Patients with serious illnesses like advanced cancer often experience existential and psychospiritual distress. Alleviating this form of pain and suffering has proven to be very challenging using conventional treatments. Psilocybin-assisted therapy (PAT) employs the psychoactive effects of psilocybin as a catalyst for a psychotherapeutic process grounded in indigenous traditions and within the...
International Journal of Whole Person Care
January 29, 2024
Houman Farzin
Despite significant advances in symptom management for patients affected by serious illness, physicians lack effective legal treatments for individuals suffering from demoralization, death anxiety, and existential distress. Psilocybin-assisted psychotherapy employs psilocybin-containing mushrooms or synthetic psilocybin grounded in indigenous traditions and within the context of a therapeutic...
Cancer Research
January 16, 2024
Kelsey Klute, Lou Lukas, Soonjo Hwang et al.
2 citations
Abstract Background: Psychological distress is a common reaction to a cancer diagnosis and its treatment. Distress impacts quality of life, adherence to treatment, decision making and survival. Patients with pancreatic adenocarcinoma (PDAC) experience exceptionally high rates of psychological distress, most commonly depression, anxiety and suicidality. Psilocybin, a serotonergic psychedelic...
Global Advances in Integrative Medicine and Health
2024
David Victorson, Kavita K Mishra, Joseph Sauer et al.
4 citations
The most common and debilitating side effects of radiation therapy (RT) for prostate cancer (PC) are fatigue, sleep disturbance, anxiety, and depression. Previous research has reported palliative benefits from certain self-management approaches, such as mindfulness meditation. To develop, pre-test, and evaluate the feasibility, acceptability and initial benefit of brief, audio-based mindfulness...
Journal of Psychopharmacology
2024
Lisa Bouchet, Zachary Sager, Antoine Yrondi et al.
22 citations
Background: Growing clinical interest in psychedelic-assisted therapies has led to a second wave of research involving psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA) and other substances. Data suggests that these compounds have the potential to treat mental health conditions that are especially prevalent in older adults such as depression, anxiety,...
Cancer
December 18, 2023
Johannes Thrul, Zofia Kozak, Michael A. Carducci et al.
5 citations
Several recent studies have investigated psilocybin as a novel therapeutic compound for the treatment of existential distress in patients with cancer, demonstrating persistent, positive effects on mood. This editorial discusses two articles in the current issue of Cancer that report findings of a group‐based psilocybin‐assisted intervention for treatment of depression in patients diagnosed with...
Palliative & Supportive Care
December 1, 2023
Roxanne Sholevar, John R Peteet, Justin J. Sanders et al.
9 citations
Psychedelic-assisted therapies (PAT) are emerging as a promising treatment for psycho-existential distress in patients with serious illness. A recent qualitative analysis of perspectives of 17 experts in serious illness care and/or PAT research identified divergent views on the therapeutic potential and safety of PAT in patients with serious illness. This paper further analyzes the factors that...
Journal of Psychedelic Studies
November 16, 2023
Danelle Jones
48 citations
Recent years have seen a global explosion in the field of psychedelic research, popularizing of use of non-ordinary states of consciousness to aid in PTSD, anxiety and depression, end of life and a growing sense that the use of substances like MDMA, psilocybin and others may become mainstream approaches to treating persistent challenges in these marginalized populations.As we destigmatize these...
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
November 5, 2023
Sara Almeida Oliveira, Victor Augusto Rodovalho Fava
A psilocibina é o princípio ativo dos cogumelos da espécie Psilocybe cubensis, historicamente conhecidos como cogumelos mágicos. É um agonista dos receptores serotoninérgicos 5HT2A. O seu uso para o tratamento do transtorno de ansiedade generalizada e da depressão em indivíduos com câncer em estágio terminal apresenta resultados promissores em ensaios clínicos. Objetivo: Revisão da literatura...