BMJ Supportive & Palliative Care
November 3, 2025
Yvan Beaussant, Zachary Sager, Caitlin W. Brennan et al.
1 citation
Objectives To assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy (PAT) for demoralisation in terminally ill patients receiving home hospice care. Methods In this open-label pilot trial, 4607 home hospice patients at a large community hospice were screened over 22 months; 66 were approached, 15 enrolled and 10 received psilocybin. Participants completed two...
Journal of Palliative Medicine
January 22, 2025
Roxanne Sholevar, William Kromka, Yvan Beaussant
10 citations
Context: Psychiatric and existential distress are common and difficult-to-treat symptoms that are frequently encountered in the palliative care setting; current treatment options are limited in efficacy and tolerability. Psychedelic-assisted therapies (PAT) have gained public and scientific interest in their potential to induce rapid and effective reductions in psychiatric and existential...
General Hospital Psychiatry
2025
Yvan Beaussant, Elise C. Tarbi, Kabir Nigam et al.
3 citations
Psilocybin-assisted therapy (PAT) shows promise for cancer-related depression, yet little research has examined how therapeutic context shapes patient experiences. While set (mindset) and setting (environment) are considered central to psychedelic treatment, empirical evidence on their role in PAT acceptability remains limited. This study explores factors influencing the acceptability of PAT...
Palliative & Supportive Care
December 1, 2023
Roxanne Sholevar, John Peteet, Justin J. Sanders et al.
9 citations
Psychedelic-assisted therapies (PAT) are emerging as a promising treatment for psycho-existential distress in patients with serious illness. A recent qualitative analysis of perspectives of 17 experts in serious illness care and/or PAT research identified divergent views on the therapeutic potential and safety of PAT in patients with serious illness. This paper further analyzes the factors that...
Psychiatric Annals
September 1, 2022
Michael Ljuslin, Kabir Nigam, Roxanne Sholevar et al.
4 citations
In addition to physical symptoms and treatment burden, people affected by serious illness experience psychological, social, and spiritual distress. Medical professionals who care for them, including psychiatrists and other mental health clinicians, attend to these multiple dimensions of suffering with the hope and promise of improving patients' quality of life. Yet anxiety, depression,...