Page 20 of 40: studies 191 to 200 of 391, newest first. Back to the end-of-life distress overview
Etudes December 30, 2025 Benjamin Guérin
Les psychothérapies assistées par psychédéliques (PAP), en anglais Psychedelic-Assisted Therapies (PAT), sont des thérapies qui supposent le recours à des substances psychotropes, telles que la psilocybine ou le LSD. En plein essor, ces psychothérapies assistées par psychédéliques semblent efficaces dans les cas de troubles dépressifs sévères ou de détresse existentielle. S’appuyant sur un...
Journal of Pain & Palliative Care Pharmacotherapy December 27, 2025 Shannon Moriarty, Anna Dushenkov, Kathleen M. Frey
Cancer patients frequently experience pain and depression, yet current guidelines address these conditions separately and do not recommend a single agent for concurrent management. Ketamine and its S-enantiomer esketamine, through N-methyl-D-aspartate receptor antagonism and glutamate modulation, may offer dual benefit. This paper examined ten clinical studies published between 2018 and 2024...
Palliative & Supportive Care December 26, 2025 Taís Oliveira Silva, Bruno Angeli-Faez, Lorena Cândida Ferreira Paixão et al.
End-of-life dreams and visions (ELDVs) and delirium frequently occur near death but differ in core features. Clinical differentiation becomes challenging when they co-occur. This case report illustrates the interplay between ELDVs and delirium, examines the limits of current diagnostic criteria in mixed cases, and outlines a nuanced approach to distinction. We report the case of an elderly...
Psychedelic Medicine December 23, 2025 Anthony L. Back, Bonnie A. Mcgregor, Lindsay Billingsley et al. 1 citation
Background: Psilocybin therapy is an emerging treatment for cancer-related anxiety, depression, and existential distress. Most clinical trials to date have studied individual models of psilocybin therapy, but group models may offer increased access and benefits of community. Purpose: This technical report describes a group facilitation model developed for an food and drug administration...
Texas Family Medicine Research Journal December 22, 2025 Larry Kravitz
This is a companion review article to a narrative medicine story in this issue of the journal. “In The Ring” is a true story of a patient’s father’s near-death experience of Hell and the history of its follow up impact on the patient and her doctor. This article explores the medical perspective on NDE’s. How are NDE’s different from other altered mental states? What about deep anesthesia...
Revista Metropolitana de Ciencias Aplicadas December 21, 2025 Graciela Estefanía Toalombo-Eugenio, Katheryne Viviana Carrillo-Zavala, Verónica Giovanna Mayorga-Núñez
Anxiety, depression, and existential distress are common symptoms in palliative care and significantly impair patients’ quality of life. Psilocybin-assisted therapy, based on preparation, therapeutic support, and psychotherapeutic integration, has emerged as a promising intervention to alleviate this complex cluster of suffering. The aim of this systematic review was to synthesize the evidence...
General Hospital Psychiatry December 10, 2025 Justin Dwyer, Robert B. Johnston, Clare O'Callaghan et al. 3 citations
This qualitative study of how successful Psychedelic Assisted Psychotherapy (PAP) transforms the way of life of terminally ill subjects provides new knowledge for researchers and clinicians contemplating its use. Using an interpretive phenomenological approach (IPA) and interviews with subjects before and after PAP from a recent randomised control trial, we find that participants with extreme...
Harm Reduction Journal December 9, 2025 Eirini K. Argyri, Joy Krecké, Oliver Robinson et al. 4 citations
Background: As the use of psychedelics increases in both therapeutic and non-clinical settings, reports of extended post-experience difficulties have also emerged. While many individuals integrate their experiences effectively, others face persistent challenges. Despite growing recognition of these issues, there is limited research on best practices for mitigating and addressing prolonged...
General Hospital Psychiatry December 9, 2025 Gerasimos Konstantinou, Joshua D. Rosenblat, Sarah Hales et al. 4 citations
The global demographic shift toward aging populations has intensified the need for innovative therapeutic interventions targeting late-life mental health conditions, notably depression, loneliness, and existential distress. Traditional pharmacological treatments often exhibit limited efficacy and poor tolerability in older patients, primarily due to age-related physiological changes and the...
Progress in Palliative Care December 1, 2025 M. Barimbing, D. Jeger, Made Edwin Sridana
ABSTRACT This narrative review synthesized the use of psilocybin-assisted therapy as a promising treatment for alleviating death anxiety in terminally ill patients. The insights presented are derived from findings reported in previous studies. Therefore, this review aimed to assess the efficacy, pharmacology, and mechanisms by which psilocybin alters brain function by affecting 5-HT2A receptors...