Evidence suggests that transcendent end-of-life experiences (ELEs) are common and impact the dying; however, there is a shortage of longitudinal studies. To evaluate the prevalence and characteristics of ELEs in terminally ill patients. This multicenter longitudinal mixed‑methods study collected demographic, clinical, and ELE‑related data-including prevalence, content, and comfort/distress...
Background Psilocybin-assisted therapy is continuing to show significant positive effects for palliative cancer patients, both in reducing symptoms and improving one’s sense of hope and meaning. Most research has focused on individual therapy models, limiting access and overlooking potential community-based benefits. Methods This qualitative study describes the results of patients experiencing...
In this editorial, I examine the parallels between conventional and assisted suicide. Psychedelic therapy has been shown to alleviate end-of-life distress and reduce suicidality. I advocate for rescheduling psychedelics to enable research into their effectiveness as an adjunct to palliative care, prior to institutionalising assisted suicide in the UK.
Many people with cancer (PWC) continue to experience persistent biopsychosocial and existential challenges across the cancer care continuum. Symptoms such as anxiety, depression, cancer-related fatigue and pain, sleep disturbance, fear of cancer recurrence, cognitive impairment, and reduced quality of life remain highly prevalent during and after treatment, underscoring the need for...
Substance use disorder (SUD) is typically treated using biomedical and psychosocial approaches that focus on reducing symptoms, regulating neurobehavioral processes, and managing behavior. While these approaches are effective for many individuals, they may not fully address the deeper challenges associated with long-term substance use, such as existential distress, disruptions in identity, and...
Although esketamine shows efficacy for treatment-resistant depression, its potential effectiveness in cancer-related depression (CRD) has not been well-established. We therefore evaluated the real-world effectiveness and safety of esketamine in CRD using a target trial emulation framework based on anonymized electronic health records from the TriNetX network. Adults aged 18-74 years with CRD...
This paper examines the relationship between women in the ger districts of Ulaanbaatar who visit and become shamans and the violence they experience. It shows that in many cases, women’s engagement with shamanism arises in the context of physical violence from their husband or male kin. Yet this paper also resists functionalist explanations that render violence as the sole cause of shamanic...
This scoping review aims to comprehensively map and synthesize the breadth of evidence from original research on the relationship between psilocybin and health, spanning clinical trials, epidemiological surveys, mechanistic experiments, and cross-sectional attitudinal studies. The review uses 145 references and builds its evidence map from 216 original studies with 271241797 total...
Objectives: Cancer and its treatment modalities, such as chemotherapy and radiotherapy, adversely affect physiological stability and psychological well-being, leading to symptoms like pain, anxiety, depression, and stress. Mind–body interventions such as guided imagery (GI) and mindfulness meditation (MM) may help alleviate these symptoms. This study aimed to evaluate and compare the...
GhaidanJune 11, 2026Rochiyatin Rifai, E. Winingsih, B. Budiyanto et al.
This case study examines the effectiveness of the Holistic-Integrative Spiritual-Transpersonal Framework (HISTF) in guidance and counseling services to strengthen the meaning of life and self-regulation of a student case at SMPN 2 Pamekasan, Madura. The phenomenon of crisis of meaning in life among adolescents is increasingly evident, as shown by World Health Organization data (2023),...