There is increasing interest in the use of psychedelics for therapeutic and recreational use. Research has been hindered by federal prohibition, put in place in 1970. Despite the regulatory difficulty, research has rapidly expanded in the past decade. Multiple states and cities have drafted their own policies regarding the use of psychedelics. Assuming interest in psychedelics continues to...
Los psicodélicos generalmente provocan un cambio profundo en la conciencia, frecuentemente con disolución del ego, experiencias místicas y una percepción sensorial enriquecida, aunque son médicamente seguros para la mayoría de las personas. La taquifilaxia ocurre tras la administración repetida de psicodélicos, lo que impide la dependencia biológica. El MDMA puede tener cierto potencial de...
Psychedelics generally elicit a profound change in consciousness, often with ego dissolution, mystical experiences, and enriched sensory perception, but are medically safe for most. Tachyphylaxis occurs after repeated psychedelic administration, preventing biological dependence. MDMA may have some abuse potential and less tachyphylaxis compared to LSD/psilocybin. Psychedelics have 5-HT2B...
BACKGROUND: Anecdotally, the concept of death consistently evokes profound unease. This study explores the intricate relationship between individuals' attitudes toward death and the associated anxiety, introducing a two-step model that posits dispositional mindfulness and tranquil ego as mediators. MATERIALS AND METHODS: We used a correlational design in this study and assessed 209 Indian...
Abstract Background Psychedelic use and its impact on well-being is garnering a lot of research attention, however, little has been done to understand the potential associations between multiple characteristics of the psychedelic experience and psychological flexibility (PF), which encompasses a conscious awareness of thoughts and behavior, allowing individuals to adapt to new experiences and...
Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution - the blurring of the distinction between representations of self and the external world. However, whether repeated use of psychedelics is associated with more prolonged and permanent modifications to the concept of self remains to be investigated. Therefore, we...
To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), in healthy participants. In all, 44 psychedelic-naïve participants enrolled in the double-blind, placebo-controlled single ascending dose study (1-12 mg BPL-003). Concentrations of 5-MeO-DMT and its...
A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5-8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here...
This chapter offers a comprehensive overview of our current understanding of the neural mechanisms underlying the effects of psychedelic drugs, with a primary focus on human neuroimaging studies. Whenever possible, we explore the neurobiological mechanisms that may underly acute and subacute adverse effects and describe hypotheses on how these results may inform on the pathophysiology of...
Background: How the human psyche interacts with the theme of death is fundamental to individual and societal life, profoundly influencing cognition, affect, and behavior. Death-related psychological phenomena, such as death anxiety and acceptance, have been shown in clinical studies to be influenced by psychedelic (LSD and psilocybin) interventions. However, the literature lacks a comprehensive...