Network neuroscience (Cambridge, Mass.)
2025
Ioanna Amaya, Till Nierhaus, Timo T Schmidt
Aberrant thalamocortical connectivity occurs together with visual hallucinations in various pathologies and drug-induced states, highlighting the need to better understand how thalamocortical interactions may contribute to hallucinatory phenomena. Flicker light stimulation (FLS) at 10-Hz reliably and selectively induces transient visual hallucinations in healthy participants. Arrhythmic flicker...
Neuroscience of Consciousness
2025
Trevor Hewitt, Ioanna Amaya, Romy Beauté et al.
Exposure to rapid and bright stroboscopic light has long been reported to induce vivid visual hallucinations of colour and geometric formations. This phenomenon was first documented by Purkinje over 200 years ago. Since then, significant progress has been made in understanding the effects of stroboscopic light and the experiences it induces through multiple waves of interest from the...
Current Topics in Behavioral Neurosciences
July 31, 2024
Nathalie M. Rieser, Timo T Schmidt, Katrin H. Preller
5 citations
This chapter offers a comprehensive overview of our current understanding of the neural mechanisms underlying the effects of psychedelic drugs, with a primary focus on human neuroimaging studies. Whenever possible, we explore the neurobiological mechanisms that may underly acute and subacute adverse effects and describe hypotheses on how these results may inform on the pathophysiology of...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
October 1, 2023
Tim Hirschfeld, Johanna Prugger, Tomislav Majić et al.
24 citations
Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here we present the first meta-analysis establishing dose-response relationship estimates of the altered states of consciousness induced by LSD. Data extracted from articles identified by a systematic literature review following PRISMA guidelines were...
Imaging neuroscience (Cambridge, Mass.)
2023
Ioanna Amaya, Marianna E. Schmidt, Marie T Bartossek et al.
The thalamus is primarily known as a relay for sensory information; however, it also critically contributes to higher-order cortical processing and coordination. Thalamocortical hyperconnectivity is associated with hallucinatory phenomena that occur in various psychopathologies (e.g., psychosis, migraine aura) and altered states of consciousness (ASC; e.g., induced by psychedelic drugs)....
Sci Data
November 23, 2022
Johanna Prugger, Ekin Derdiyok, Jannis Dinkelacker et al.
36 citations
In this paper, we present the development of the Altered States Database (ASDB), an open-science project based on a systematic literature review. The ASDB contains psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC) induced by pharmacological and non-pharmacological methods. The systematic review follows the Preferred Reporting Items for Systematic...
Scientific Data
2022
Cyril Costines, Ekin Derdiyok, Jannis Dinkelacker et al.
In this paper, we present the development of the Altered States Database (ASDB), an open-science project based on a systematic literature review. The ASDB contains psychometric questionnaire data on subjective experiences of altered states of consciousness (ASC) induced by pharmacological and non-pharmacological methods. The systematic review follows the Preferred Reporting Items for Systematic...
Journal of Psychopharmacology
March 4, 2021
Tim Hirschfeld, Timo T Schmidt
90 citations
Background: Psilocybin is the psychoactive component in Psilocybe mushrooms (‘magic mushrooms’). Whether and how the quality of the psilocybin-induced experience might mediate beneficial health outcomes is currently under investigation, for example, in therapeutic applications. However, to date, no meta-analysis has investigated the dose-dependency of subjective experiences across available...
Journal of Psychopharmacology
February 9, 2015
Tomislav Majić, Timo T Schmidt, Jürgen Gallinat
267 citations
Interest in the therapeutic potential of psychedelic substances has recently resumed. During an early phase of human psychedelic research, their therapeutic application in different pathologies had been suggested, and the first evidence for efficacy was provided. The range of recent clinical applications of psychedelics spans from cluster headaches and obsessive-compulsive disorder to addiction...