Introduction MM120 (lysergide D-tartrate, a formulation of LSD) is under development as a potential treatment for generalized anxiety and major depressive disorders. How psychedelic drugs interact at the TrkB receptor, a key target of neuroplasticity, is not reported. Objectives The study evaluated binding and functional activity of known serotonergic psychedelic compounds and SRI fluoxetine at...
Abstract The last decade has seen a remarkable resurgence of interest in psychedelic drugs such as psilocybin (from magic mushrooms) LSD and DMT (dimethyl tryptamine – the active ingredient of ayahuasca). This has been driven by the discovery that these psychedelics all act agonists of 5-HT2A receptors plus human imaging studies that reveal this action leads to profound alterations in brain...
Introduction Research on psychedelic compounds has grown quickly in the past decade. Yet molecule-specific, quantitative summaries are scattered, making it hard to see how interest differs by compound or over time. Objectives To quantify PubMed-indexed publications on ketamine, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), psilocybin, and psilocin; to describe annual trends...
Opioid use disorder (OUD) remains a major public health crisis in the United States, with mental health disorders substantially increasing risk severity. Emerging evidence suggests psychedelics may relate to reduced OUD risk. This exploratory study examined associations between lifetime psychedelic use and OUD severity and tested whether these associations varied by mental health impairment....
Brain waves are ubiquitous phenomena of human brain activity. As they propagate, they coordinate neural communication, shaping conscious perception. Understanding how brain waves unfold across space and time is thus critical for uncovering the neural mechanisms that support and suppress consciousness. Here, we analyzed data from the Human Connectome Project alongside multiple independent human...
Expectations strongly shape participant experiences in clinical trials, contributing to placebo effects that complicate interpretation of outcomes. While quantitative tools exist to measure expectations, their subjective and multidimensional nature, especially for individuals with treatment-resistant depression (TRD), remains underexplored. This study aimed to explore the motivations and...
PsychedelicsMay 30, 2026Vinicius Ryu Kami, Beatriz Borges Bueno Salle, Giovanni Porto et al.
Background Contemporary psychiatry is associated with several challenges, including limited remission rates in complex and severe psychiatric disorders. In this context, psychedelics have re-emerged globally as a promising therapeutic paradigm. Brazil occupies a unique position in this scenario, mainly due to the legal protection and cultural integration of Ayahuasca, which fosters a distinct...
Despite renewed investigations into classical psychedelic compounds, their pharmacokinetic profiles remain incompletely understood. This systematic review collated data from healthy adult volunteers on the pharmacokinetic properties of lysergic acid diethylamide (LSD), psilocybin, dimethyltryptamine (DMT), mescaline, and 5-methoxy-N,N-dimethyltryptamine (5-MEO-DMT). We identified 32 eligible...
A medição e quantificação precisas da consciência humana permanecem um dos desafios mais significativos na neurociência e física modernas. As Interfaces Cérebro-Computador (ICCs) tradicionais focam na decodificação de intenções motoras localizadas, tratando o cérebro como um gerador de comandos isolado. Baseando-se no conceito de Schrödinger de vida como organização informacional, no Princípio...
This paper provides a critical desk-based review of the relationship between the pineal gland and “hyperdimensional wisdom” by drawing on neuroendocrinology, consciousness studies, religious and cultural history, and public science narratives. It does not define hyperdimensional wisdom as objective knowledge from higher-dimensional space, nor does it treat the pineal gland as an empirically...