Psychedelics a class of psychoactive compounds such as psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) are undergoing a scientific renaissance. Studies since 2020 have shown their therapeutic promise in mental health treatment. This Commentary synthesizes historical usage, current neuroscientific and clinical evidence, and explores ethical and regulatory frontiers for...
Importance: Psychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity of efficacy estimates and regulatory acceptance. Objective: To...
Mitochondrial dysfunction is increasingly recognized as a central driver of Alzheimer's disease (AD), contributing to neuroinflammation, synaptic failure, and energy collapse.Emerging preclinical evidence suggests that classic hallucinogens, such as psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline, may restore mitochondrial integrity by activating Serotonin...
O presente artigo propõe a formalização da Computação Simbiótica Biomimética (CSB) como campo científico emergente, fundamentado na Arquitetura Holográfica da Construção da Realidade 2.0 (AHCR 2.0). A CSB é definida como o conjunto de princípios, métodos e tecnologias que imitam o funcionamento funcional do cérebro humano para criar interfaces bidirecionais entre domínios biológicos e...
This article reviews the current clinical evidence for psilocybin and ayahuasca as therapeutic agents, examining data from over 134 registered clinical trials and key publications in the New England Journal of Medicine, JAMA, JAMA Psychiatry, and Nature Neuroscience. The review addresses four dimensions: (1) the state of clinical evidence for psilocybin and ayahuasca in major depression and...
A depressão é uma das principais causas de incapacidade no mundo, e suas abordagens terapêuticas convencionais, embora eficazes para muitos pacientes, ainda apresentam limitações significativas, como início tardio dos efeitos e resistência ao tratamento. Nesse contexto, destaca-se a hoasca, também conhecida como ayahuasca, uma infusão amazônica tradicional composta por Banisteriopsis caapi e...
Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co-occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone. Current therapies often address each disorder in isolation, leaving individuals with comorbid MDD and chronic pain...
-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant species traditionally used in shamanic rituals for spiritual healing. Leveraging the similarities in their chemical structures, we reconstructed in one plant assay the full biosynthetic pathways of five renowned natural psychedelics; psilocin and psilocybin found in mushrooms, DMT from plants, and bufotenin and 5-methoxy-DMT...
Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented...
AdiccionesMarch 31, 2026Bernardino Barceló Martín, José Manuel Arteaga Armas, Isabel Gomila Muñiz et al.
Se recomienda la inclusión de la DMT en los protocolos de sumisión química en los que se sospeche la asistencia de las víctimas a rituales espirituales o cuando las pacientes refieren haber sufrido breves pero intensas alucinaciones visuales y auditivas. La posibilidad de que la DMT provoque resultados falsos positivos en los cribados de anfetaminas permite sospechar su presencia. No obstante,...