The International Journal of Neuropsychopharmacology
September 9, 2026
J Ramaekers
Abstract Background Short-acting psychedelics such as 5-MeO-DMT and DMT may induce rapid relief of depressive symptoms after brief but intense psychedelic experiences. Aims & Objectives This presentation examines their clinical pharmacology and therapeutic potential in depression. Method Review of clinical data. Results Both compounds primarily target serotonergic receptors, notably 5-HT1A and...
Zenodo (CERN European Organization for Nuclear Research)
September 7, 2026
Flávio Marco Rego da Silva
preprint
Rationale: Increased neural complexity under psychedelics is replicated, but the temporal structure carrying it — and the design choices that decide what a "complexity increase" means — remain contested: window-level reports treat correlated windows as independent; cross-dataset contrasts confound pharmacology with protocol. Objectives: To test, in public EEG datasets with pre-registered...
The International Journal of Neuropsychopharmacology
September 1, 2026
Bernhard T Baune, T. Benway, D. Gregory et al.
Abstract Background Treatment-resistant depression (TRD) is a chronic condition affecting approximately 30% of patients with major depressive disorder, posing a significant unmet need for safe and effective treatments. GH001, an inhaled formulation of mebufotenin (5-MeO-DMT), has shown good tolerability and safety in early stage clinical trials in healthy volunteers and patients with TRD. Aims...
The International Journal of Neuropsychopharmacology
September 1, 2026
W. Cubała, Kelly Doolin, Fiona Ryan et al.
Abstract Background Treatment-resistant depression (TRD) represents a particularly challenging form of major depressive disorder (MDD), defined by an inadequate response to at least two antidepressants given at adequate dose and duration within the current depressive episode. TRD affects nearly one-third of individuals with MDD and is consistently linked to greater psychiatric and medical...
The International Journal of Neuropsychopharmacology
September 1, 2026
Christopher Sheridan, Guillaume Thuery, K Brennan et al.
Abstract Background Serotonergic psychedelics have recently re-emerged as promising therapeutic agents in psychiatry, showing positive outcomes in clinical trials for treatment-resistant depression, major depression, and PTSD. However, their effects on the immune system are poorly characterized. It remains unclear whether these compounds exert immunomodulatory effects that contribute to their...
Nursing Edição Brasileira
August 27, 2026
Ana Júlia Costa Matias Gomes, Jéssica Camilo Ramos Rodrigues, Valber Pinheiro Padilha Filho
Os psicodélicos clássicos, como a psilocibina, o LSD e a DMT, têm despertado crescente interesse na psiquiatria moderna devido ao seu potencial terapêutico em transtornos resistentes ao tratamento. O mecanismo de ação primário dessas substâncias envolve o agonismo dos receptores de serotonina 5-HT2A, localizados principalmente no córtex pré-frontal. Esta revisão sistemática analisou como a...
ACS Pharmacology & Translational Science
August 18, 2026
Richard A Glennon, Maƚgorzata Dukat
Abstract Isotryptamines, or 2-(1-indolyl)ethylamines, are positional or geometric isomers of tryptamines where the aminoethyl substituent has been relocated from the indole 3-position to the N1-position. Early studies with these types of agents relied on peripheral tissue assays for examination of their serotonin (5-hydroxytryptamine; 5-HT) receptor affinities to investigate structure–affinity...
International Journal For Multidisciplinary Research
August 16, 2026
Eric P. Rubenstein
Ayahuasca is traditionally prepared by aqueous extraction and concentration of Banisteriopsis caapi and Psychotria viridis. The resulting beverage contains N,N-dimethyltryptamine (DMT), harmine, harmaline, tetrahydroharmine (THH), additional alkaloids, polyphenolic constituents, carbohydrates, organic acids, suspended solids, and numerous other plant-derived compounds. The source plants are...
The Natural Products Journal
August 12, 2026
Weslany Souza Rocha, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior et al.
Introduction: Mimosa tenuiflora (Willd.) Poir., widely known as Jurema preta in Brazil and tepezcohuite in Mexico, is a perennial shrub or tree traditionally used in folk medicine across the Caatinga biome of northeastern Brazil and other regions of Central and South America. Tryptamine is an indole alkaloid naturally found in several species, with M. tenuiflora representing an important...
Contemporary Drug Problems
August 11, 2026
Alana Roy, M.l. Williams, Kimberley Day et al.
Alternative healthcare practices using psychedelic “plant medicines,” such as ayahuasca, challenge current prohibition and mainstream healthcare frameworks. Despite the criminalization of ayahuasca's active component, N,N-dimethyltryptamine (DMT), Australian ayahuasca dietero networks have developed sophisticated healthcare systems with systematic assessment processes, safety mechanisms, and...