European Neuropsychopharmacology
June 2018
Lejla Colic, Marie Woelfer, Merima Colic et al.
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long-term impact on blood parameters has not yet been described in clinical studies....
Canadian journal of anaesthesia = Journal canadien d'anesthesie
June 2018
Jonathan J Gamble, Henry Bi, Rudy Bowen et al.
Major depressive disorder (MDD) is a common and debilitating condition that can be challenging to treat. Electroconvulsive therapy (ECT) is currently the therapeutic gold standard for treatment-resistant MDD. We tested our hypothesis that ketamine-based anesthesia for ECT results in superior improvement in treatment-resistant MDD outcomes compared with propofol-based anesthesia. Patients with...
Neuropsychiatric Disease and Treatment
June 1, 2018
Vytautas Jankauskas, Candace Necyk, James Chue et al.
17 citations
Up to 20% of depressed patients demonstrate treatment resistance to one or more adequate antidepressant trials, resulting in a disproportionately high burden of illness. Ketamine is a non-barbiturate, rapid-acting general anesthetic that has been increasingly studied in treatment resistant depression (TRD), typically at sub-anesthetic doses (0.5 mg/kg over 40 min by intravenous infusion). More...
Psychiatria Danubina
June 1, 2018
Jiao Yang, Siyuan Tang, Wenchao Zhou
BACKGROUND Psychiatric nurses are a special group of nursing staff, they experience greater work stress and lower mental health levels than regular nurses. In order to address this problem, the effect of mindfulness-based stress reduction (MBSR) therapy on work stress and mental health of psychiatric nurses is investigated in this study. SUBJECTS AND METHODS From August 2017 to November 2017,...
Dreaming
June 1, 2018
K. Miller, Joanne L. Davis, Jamie L Rhudy
Previous research on an efficacious cognitive-behavioral treatment for posttrauma nightmares and sleep disturbances (exposure, relaxation, and rescripting therapy; ERRT) has not tested the treatment in individuals with bipolar disorder. However, research suggests that individuals diagnosed with bipolar disorder are at increased risk for trauma exposure and development of posttrauma symptoms....
Nurse Education Today
June 1, 2018
P. van der Riet, T. Levett-Jones, Catherine Aquino-Russell
BACKGROUND A growing body of literature has identified a range of beneficial physiological and psychological outcomes from the regular practice of mindfulness meditation. For healthcare professionals, mindfulness meditation is claimed to reduce stress, anxiety and burnout, and enhance resilience. OBJECTIVE The objective of this integrative review was to critically appraise the literature that...
International Journal of Clinical and Experimental Hypnosis
June 1, 2018
David R Patterson, C. Hoffer, M. Jensen et al.
8 citations
Abstract This pilot study explored the feasibility of using ketamine to increase hypnotizability scores. Ketamine, classified as a dissociative hallucinogen, is used clinically as an anesthetic in high doses and as a treatment for chronic pain and depression in lower doses. Low-dose ketamine can contribute to dissociation and heightened perceptions and feelings of detachment, arguably...
Cell Reports
June 1, 2018
Calvin Ly, Alexandra C. Greb, Lindsay P. Cameron et al.
1,158 citations
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of...
Crisis
May 31, 2018
Megan S Chesin, Beth S. Brodsky, Brandon Beeler et al.
19 citations
BACKGROUND: Few investigations of patient perceptions of suicide prevention interventions exist, limiting our understanding of the processes and components of treatment that may be engaging and effective for high suicide-risk patients. AIMS: Building on promising quantitative data that showed that adjunct mindfulness-based cognitive therapy to prevent suicidal behavior (MBCT-S) reduced suicidal...
Mindfulness
May 31, 2018
Felipe A Jain, P. Fonagy
Facilitating mentalization, or the ability to understand mental states and their link to behavior, is increasingly viewed as a common mechanism of action across effective psychotherapies. Here, we present an overview of a new set of contemplative psychotherapeutic techniques, mentalizing imagery therapy (MIT), which uses guided imagery and mindfulness practices to facilitate mentalization. MIT...