European Archives of Psychiatry and Clinical Neuroscience
June 2018
Eliza Hoxhaj, C Sadohara, P Borel et al.
Mindfulness training is a promising treatment approach in adult ADHD. However, there has not yet been a randomized controlled trial comparing mindfulness to an active control condition. In this study, we assessed the efficacy of a mindfulness training program (MAP) compared to structured psychoeducation (PE). After randomization 81 medication-free adult ADHD patients participated either in an...
BMC Pregnancy and Childbirth
June 1, 2018
Cassandra Vieten, Barbara A. Laraia, Jean L. Kristeller et al.
79 citations
BACKGROUND: Pregnancy is a time of high risk for excessive weight gain, leading to health-related consequences for mothers and offspring. Theory-based obesity interventions that target proposed mechanisms of biobehavioral change are needed, in addition to simply providing nutritional and weight gain directives. Mindfulness training is hypothesized to reduce stress and non-homeostatic eating...
Frontiers in Psychology
June 1, 2018
Marlene V. Strege, Deanna M. Swain, Lauren Ann Bochicchio et al.
34 citations
Randomized controlled trials have demonstrated that mindfulness-based cognitive therapy (MBCT) is efficacious in reducing residual depressive symptoms and preventing future depressive episodes (Kuyken et al., 2016). One potential treatment effect of MBCT may be improvement of positive affect (PA), due to improved awareness of daily positive events (Geschwind, Peeters, Drukker, Van Os, &...
Psychology, Health & Medicine
June 2018
Wu-Jeong Hwang, Tae Young Lee, Kyung-Ok Lim et al.
The interest in mindfulness meditation interventions has surged due to their beneficial effects in fostering resilience and reducing stress in both clinical and non-clinical populations. However, the relaxation benefits that may occur while practicing mindfulness meditation and long-term benefits of these interventions remain unclear. Fifty-one participants were recruited and randomized into...
Behavioural Brain Research
June 1, 2018
Emilia Tarland, J. Brosda
HighlightsSubchronic PCP treatment did not interfere with olfactory function in male rats.Olfactory exploratory motivation was unaltered by subchronic PCP.Male rats treated with subchronic PCP spent more time investigating a novel social odour. ABSTRACT The olfactory system participates in many sensory processes, and olfactory endophenotypes appear in a variety of neurological disorders such as...
Biochimica et biophysica acta. General subjects
June 2018
Andréa T Faccio, Francisco J Ruperez, Nagendra S. Singh et al.
Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant effects of (R,S)-ketamine have been linked to its conversion into (2S,6S;2R,6R)-hydroxynorketamine (HNK); however, the connection between structure and stereochemistry of ketamine and HNK in the...
Biochemical Pharmacology
June 2018
Ming-Fen Ho, Cristina Correia, James N Ingle et al.
Major depressive disorder (MDD) is the most common psychiatric illness worldwide, and it displays a striking sex-dependent difference in incidence, with two thirds of MDD patients being women. Ketamine treatment can produce rapid antidepressant effects in MDD patients, effects that are mediated-at least partially-through glutamatergic neurotransmission. Two active metabolites of ketamine,...
European Neuropsychopharmacology
June 2018
Lejla Colic, Marie Woelfer, Merima Colic et al.
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long-term impact on blood parameters has not yet been described in clinical studies....
Canadian journal of anaesthesia = Journal canadien d'anesthesie
June 2018
Jonathan J Gamble, Henry Bi, Rudy Bowen et al.
Major depressive disorder (MDD) is a common and debilitating condition that can be challenging to treat. Electroconvulsive therapy (ECT) is currently the therapeutic gold standard for treatment-resistant MDD. We tested our hypothesis that ketamine-based anesthesia for ECT results in superior improvement in treatment-resistant MDD outcomes compared with propofol-based anesthesia. Patients with...
Neuropsychiatric Disease and Treatment
June 1, 2018
Vytautas Jankauskas, Candace Necyk, James Chue et al.
17 citations
Up to 20% of depressed patients demonstrate treatment resistance to one or more adequate antidepressant trials, resulting in a disproportionately high burden of illness. Ketamine is a non-barbiturate, rapid-acting general anesthetic that has been increasingly studied in treatment resistant depression (TRD), typically at sub-anesthetic doses (0.5 mg/kg over 40 min by intravenous infusion). More...