Cancer Nursing
November 16, 2018
Jouhayna Bajjani-Gebara, P. Hinds, Kathleen C Insel et al.
BACKGROUND Childhood cancer profoundly impacts the well-being of many parental caregivers in the United States yearly. Empirical evidence is extensive for negative well-being and scarce for positive well-being in this population. OBJECTIVE Study aims were to (1) describe resilience, self-transcendence, and positive (general well-being) and negative well-being (depression and anxiety); (2)...
The Brown University Psychopharmacology Update
November 14, 2018
A placebo‐controlled study in which participants with treatment‐resistant depression received naltrexone prior to infusion of ketamine found that the opioid antagonist blocked ketamine's antidepressant effects but not the dissociation induced by ketamine. These findings suggest that the antidepressant effect of ketamine requires activation of the opioid system.
The International Journal of Neuropsychopharmacology
November 14, 2018
Bashkim Kadriu, Laura Musazzi, Ioline D. Henter et al.
164 citations
The underlying neurobiological basis of major depressive disorder remains elusive due to the severity, complexity, and heterogeneity of the disorder. While the traditional monoaminergic hypothesis has largely fallen short in its ability to provide a complete picture of major depressive disorder, emerging preclinical and clinical findings suggest that dysfunctional glutamatergic...
OBM Integrative and Complementary Medicine
November 5, 2018
Nancy Poirier, Serge Beaulieu, Sybille Saury et al.
Background: This study investigated variations in psychic and somatic anxiety during and after completion of MBCT compared to baseline in patients diagnosed with BD. Secondary variables considered were sleep quality and quality of life, as well as depressive and manic symptoms. Methods: HAMD-29, HAMD-7 and YMRS were administered at baseline (n=34), and every two weeks until the end of the...
International Journal of Psychiatry in Clinical Practice
November 2018
Angela Potes, Gabriel Souza, Katerina Nikolitch et al.
This systematic review summarises the current state of research on mindfulness in SPMI, given the pressing need to provide alternative, scalable and cost-effective treatment modalities for patients with severe and persistent mental illness (SPMI). Articles included mindfulness-based interventions for SPMI. Excluded articles included qualitative studies, acceptance and compassion therapies, case...
Neuropsychopharmacology
November 2018
Lakshmi Rajagopal, Mei Huang, Eric Michael et al.
GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABAA α2,3 subtype-selective GABAA partial...
Psychopharmacology
November 2018
Kai Zhang, Hidetoh Toki, Yuko Fujita et al.
(R,S)-ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, exhibits rapid and long-lasting antidepressant effects and anti-suicidal ideation in treatment-resistant patients with depression. However, the precise mechanisms underlying the antidepressant actions of (R,S)-ketamine are unknown. Although the previous report demonstrated the deuterium isotope effects in the antidepressant...
Brain and nerve = Shinkei kenkyu no shinpo
November 2018
Kazuhiko Fukuda
The phenomenon called kanashibari in Japan is otherwise known as sleep paralysis and, is an established symptom of narcolepsy. Its physiological correlate is an unusual occurrence of rapid eye movement (REM) sleep, i.e., sleep onset REM periods (SOREMPs). Various symptoms of the phenomenon are explained by the mechanisms of REM sleep. SOREMPs can be observed in various situations, which...
The International Journal of Neuropsychopharmacology
November 1, 2018
Bruna Cuccurazzu, Erica Zamberletti, Cristiano Nazzaro et al.
In rodent models, chronic exposure to cannabis' psychoactive ingredient, Δ9-tetrahydrocannabinol, during adolescence leads to abnormal behavior in adulthood. In female rats, this maladaptive behavior is characterized by endophenotypes for depressive-like and psychotic-like disorders as well as cognitive deficits. We recently reported that most depressive-like behaviors triggered by adolescent...
Neuropharmacology
November 2018
I Ivan Ezquerra-Romano, W Lawn, E Krupitsky et al.
Ketamine is a dissociative anaesthetic drug which acts on the central nervous system chiefly through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Recently, ketamine has attracted attention as a rapid-acting anti-depressant but other studies have also reported its efficacy in reducing problematic alcohol and drug use. This review explores the preclinical and clinical research into...