Brain and nerve = Shinkei kenkyu no shinpo
October 2025
Takashi Nomura
Parasomnia is an undesirable physical phenomena that occurs during sleep and is classified into three groups: non-rapid eye movement (REM), REM, and other parasomnias. Non-REM parasomnias that occur during non-REM sleep include wakefulness disorders, including confusional arousal, sleepwalking, sleep terrors, and newly added sleep-related eating disorders. REM sleep parasomnias related to dream...
Brain and nerve = Shinkei kenkyu no shinpo
December 1, 2023
Hiroyuki Uchida
In recent years, there has been a growing movement to apply psychedelic drugs for treating psychiatric disorders, including depression. Although the therapeutic effects of psychedelic drugs were verified in the 1960s, their abuse by the public led to their designation as narcotics in 1970, and clinical research on them was suspended for a time. However, since 1994, clinical trials have been...
Brain and nerve = Shinkei kenkyu no shinpo
November 2018
Kazuhiko Fukuda
The phenomenon called kanashibari in Japan is otherwise known as sleep paralysis and, is an established symptom of narcolepsy. Its physiological correlate is an unusual occurrence of rapid eye movement (REM) sleep, i.e., sleep onset REM periods (SOREMPs). Various symptoms of the phenomenon are explained by the mechanisms of REM sleep. SOREMPs can be observed in various situations, which...
Brain and nerve = Shinkei kenkyu no shinpo
August 2018
Yoshiyuki Nishio
Visual impairment and visual hallucinations are diagnostic signposts of dementia with Lewy bodies (DLB). Visual impairment is easily explicable as a functional impairment that results from damage to the visual cortices, whereas there is currently no compelling explanations for the mechanisms of visual hallucinations and other false perceptions. Here, I review evidence regarding the...
Brain and nerve = Shinkei kenkyu no shinpo
March 2018
Shigeyuki Kan, Satoru Miyauchi
Emerging evidence indicates that cortical midline structures (CMS) (which consist of the orbitomedial prefrontal cortex (OMPFC), dorsomedial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), and precuneus/posterior cingulate cortex (pC/PCC)) have a critical role in generating a model of the self. These regions also serve as hub regions for the default mode network (DMN) or salience...
Brain and nerve = Shinkei kenkyu no shinpo
October 2017
Kenji Hashimoto
Depression is often misdiagnosed as major depressive disorder in patients with bipolar disorder. Therapeutic drugs for these two disorders are quite different, but the anesthetic ketamine shows fast-acting antidepressant effects in treatment-resistant patients with these disorders. Here, we discuss biomarkers for both disorders, recent findings regarding ketamine, and predictable biomarkers for...