Background and objectives: Family caregivers of people with dementia (PWD) experience high levels of stress resulting from caregiving. This study aimed to investigate the effects of a modified of Mindfulness-Based Cognitive Therapy (MBCT) for dementia caregiving. Research design and methods: 113 family caregivers of PWD were randomized to either the intervention group, receiving the 7-session...
Patients with functional dyspepsia (FD) often have concomitant anxiety and depression. Mindfulness-based cognitive therapy (MBCT) combines the principles of cognitive behavioral therapy and mindfulness. It is a group-based therapy and has been shown to be efficacious in functional gastrointestinal disorders. There are no randomized controlled trials (RCTs) evaluating MBCT in FD. We aimed to...
Meta-analyses suggest that dance has potential to decrease psychological distress, increase trait mindfulness, and enhance quality of life. Conscious dance can be defined as unchoreographed, intentionally nonevaluative mindful movement commonly practiced in a group setting for purposes of authentic self-expression, self-discovery, interpersonal connectedness, and personal healing or growth. To...
To update pharmacological insights on ketamine integrating information from different disciplines for developing steps to "breakthrough" approaches in clinical challenges. Pharmacokinetic/pharmacodynamic (PK/PD) models have incorporated recirculation, ketamine metabolites, drug-drug interaction, and covariates such as age. Ketamine-induced relief from treatment-resistant depression has been...
Increased glutamatergic neurotransmission and synaptic plasticity in the prefrontal cortex have been associated with the rapid antidepressant effects of ketamine. Activation of BDNF (brain-derived neurotrophic factor) receptor TrkB is considered a key molecular event for antidepressant-induced functional and structural synaptic plasticity. Several mechanisms have been proposed to underlie...
SUMMARY Ketamine produces rapid antidepressant action in patients with major depression or treatment-resistant depression. Studies have identified brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), as necessary for the antidepressant effects and underlying ketamine-induced synaptic potentiation in the hippocampus. Here, we delete BDNF or TrkB in...
Philosophy of Psychedelics is the first scholarly monograph in English devoted to the philosophical analysis of psychedelic drugs. Its central focus is the apparent conflict between the growing use of psychedelics in psychiatry and the philosophical worldview of naturalism, which holds that the natural world is all that exists. The book reviews scientific evidence that psychedelics such as...
‘On the need for a natural philosophy of psychedelics’ provides a brief overview of the history of psychedelics in science and psychiatry, and a detailed review of recent evidence for their therapeutic and transformative efficacy. The chapter reviews clinical trials showing that one or two controlled psychedelic experiences can durably reduce symptoms of anxiety, depression, and addiction, and...
ReligionsJuly 31, 2021Raquel Vilanova Araújo, A. F. C. Fernandes, R. I. C. Campelo et al.
Objective: To evaluate the effect of Raja yoga meditation on the level of distress and anxiety in women with breast cancer. Method: A randomized, controlled, clinical trial was carried out in a specialized center between February and December 2019. The patients in the intervention group (n = 25) participated in four group meditation sessions for one month, and the participants in the control...
July 31, 2021Shelley R. Upton, Tyler L. Renshaw, Amanda Morice
preprint
Mindfulness is a traditional, sacred Buddhist practice that has entered the mainstream of applied psychology and become secularized. This study examined the differential influence of the presentation priming of mindfulness meditation—as either a “sacred Buddhist practice” (sacred condition) or a “scientifically proven tool” (secular condition)—on its therapeutic effectiveness in a general...