A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action
Cell Reports August 1, 2021 Pei-Yi Lin, Z. Z. Ma, Melissa Mahgoub et al. 97 citations
SUMMARY Ketamine produces rapid antidepressant action in patients with major depression or treatment-resistant depression. Studies have identified brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), as necessary for the antidepressant effects and underlying ketamine-induced synaptic potentiation in the hippocampus. Here, we delete BDNF or TrkB in...