Current Opinion in Anaesthesiology
April 11, 2025
María T Fernández Martin, Servando Lopez Alvarez, Cesar Aldecoa Alvarez-Santullano
4 citations
To update published data about adjuvants and examine their evolution in use over the last 2 years. This scoping review highlights current and updated published evidence on using adjuvants and future research directions.Regional techniques (including peripheral nerve blocks) have become relevant for pain relief and postoperative quality recovery. Examples of adjuvant drugs for regional...
Current Opinion in Anaesthesiology
October 1, 2021
Irene Rozet
9 citations
Purpose of review The antidepressant effect of subanesthetic doses of ketamine was recognized 20 years ago. This review briefly summarizes the current understanding of the antidepressant mechanisms and the available clinical research on the use of racemic ketamine and enantiomer esketamine for depression. Recent findings The antidepressant effect of subanesthetic doses of ketamine is currently...
Current Opinion in Anaesthesiology
August 1, 2021
Sabine Himmelseher, Eberhard F Kochs
To update pharmacological insights on ketamine integrating information from different disciplines for developing steps to "breakthrough" approaches in clinical challenges. Pharmacokinetic/pharmacodynamic (PK/PD) models have incorporated recirculation, ketamine metabolites, drug-drug interaction, and covariates such as age. Ketamine-induced relief from treatment-resistant depression has been...
Current Opinion in Anaesthesiology
August 1, 2018
Scott C. Tadler, Brian J Mickey
After decades without substantial advances, multiple novel antidepressants show promise against treatment-resistant depression. Interestingly, many of these are anesthetics. The purpose of this review is to discuss the evidence for the antidepressant effects of ketamine, nitrous oxide, isoflurane and propofol and to consider potential clinical, administrative and research implications for...
Current Opinion in Anaesthesiology
August 2018
Kathryn Cobb, Monika Nanda
Anesthetics, such as thiopental, methohexital, propofol and ketamine have been used to induce unconsciousness for electroconvulsive therapy (ECT), each with its advantages and disadvantages. Only until recently was it discovered that ketamine may have inherent antidepressant effects. We reviewed the side effect profile of ketamine and examined the literature for whether or not ketamine augments...