Translational Psychiatry
February 24, 2024
Rachael Sumner, Rebecca McMillan, Anna Forsyth et al.
7 citations
Revealing the acute cortical pharmacodynamics of an antidepressant dose of ketamine in humans with depression is key to determining the specific mechanism(s) of action for alleviating symptoms. While the downstream effects are characterised by increases in plasticity and reductions in depressive symptoms-it is the acute response in the brain that triggers this cascade of events. Computational...
International Immunopharmacology
February 23, 2024
Salma Laabi, Claire LeMmon, Callie Vogel et al.
16 citations
A decade of clinical research has indicated psilocybin's effectiveness in treating various neuropsychiatric disorders, such as depression and substance abuse. The correlation between increased pro-inflammatory cytokines and the severity of neuropsychiatric symptoms, along with the known anti-inflammatory potential of some psychedelics, suggests an immunomodulatory role for psilocybin. This...
Journal of Education, Health and Sport
February 22, 2024
Krzysztof Marcinkowski, Agata Mazur, Magdalena Madera et al.
Introduction and purpose: Post-traumatic stress disorder is a psychiatric condition following an extreme event that causes a near death of an involved individual. Since conventional treatments using selective serotonin reuptake inhibitors do not consistently yield therapeutic success, alternative substances are being explored as potential solutions. This study aims to compile information...
Research Square
February 22, 2024
Martha N. Havenith, Max Leidenberger, Jelena Brasanac et al.
3 citations
preprint
Abstract Altered states of consciousness (ASCs), induced e.g. by psychedelics, show great potential to treat widespread mental health disorders like depression and PTSD. However, access to such treatments is restricted by legal, medical, and financial barriers. Here, we explore the potential of circular breathwork to serve as an accessible, non-pharmacological alternative to engage similar...
February 20, 2024
Joost J. Breeksema
Psychedelics are remarkable, versatile substances that produce a wide range of effects and can cause both harm and healing. Clinical research into psychedelic treatments is booming. In spite of this renewed interest, relatively little is known about how patients experience these treatments. In this dissertation, patients who received a psychedelic (either ketamine or psilocybin) to a treat...
Journal of Health and Rehabilitation Research
February 17, 2024
Nabeela Raza, Anum Farooq
Background: Sleep paralysis is a transient and often distressing condition characterized by an inability to move or speak during the transition between wakefulness and sleep. Previous studies have highlighted a higher prevalence of sleep paralysis in psychiatric populations compared to the general population, yet comprehensive comparative studies remain scarce. Understanding the nuances of...
World Futures
February 17, 2024
Azul Delgrasso
4 citations
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic and entheogenic compound that has been used for centuries by Indigenous Peoples in the Amazon, Caribbean, and more recently in communities in Northern Mexico in ceremonial practices and to connect with nature. In recent years, there has been growing interest in 5-MeO-DMT to treat mental health conditions such as depression, anxiety...
Neuroscience
February 16, 2024
Douglas Funk, Joseph Araujo, Malik Slassi et al.
11 citations
Psilocybin has received attention as a treatment for depression, stress disorders and drug and alcohol addiction. To help determine the mechanisms underlying its therapeutic effects, here we examined acute effects of a range of behaviourally relevant psilocybin doses (0.1-3 mg/kg SC) on regional expression of Fos, the protein product of the immediate early gene, c-fos in brain areas involved in...
Cochrane Database of Systematic Reviews
February 15, 2024
Karen Rees, Andrea Takeda, Rachel Court et al.
15 citations
Interventions incorporating meditation to address stress, anxiety, and depression, and improve self-management, are becoming popular for many health conditions. Stress is a risk factor for cardiovascular disease (CVD) and clusters with other modifiable behavioural risk factors, such as smoking. Meditation may therefore be a useful CVD prevention strategy. To determine the effectiveness of...
AJNR. American journal of neuroradiology
February 15, 2024
Paloma C Frautschi, Ajay P Singh, Nicholas A Stowe et al.
5 citations
The neurobiological mechanisms underpinning psychiatric disorders such as treatment-resistant major depression, post-traumatic stress disorder, and substance use disorders, remain unknown. Psychedelic compounds, such as psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine, have emerged as potential therapies for these disorders because of their hypothesized ability to induce...