ACS Chemical Neuroscience
March 5, 2025
Syed Muzzammil Masaud, Humaira Nadeem, Babar Murtaza et al.
3 citations
This study investigated the synthesis, characterization, and in silico analysis of novel N-acetamide ketamine derivatives aimed at evaluating their analgesic, anesthetic, and antidepressant properties. The synthesis commenced with the preparation of chloroacetylamide derivatives, which were subsequently reacted with ketamine hydrochloride, yielding 16 derivatives k1 to k16. These compounds were...
BMC Medical Education
March 5, 2025
Helena Aicher, F Müller, Peter Gasser
11 citations
The growing interest in psychedelic-assisted therapy (PAT) for treating psychiatric disorders such as treatment-resistant depression, PTSD, and anxiety has led to an increasing demand for specialized training. In Switzerland, MDMA, psilocybin, and LSD are applied in the framework of limited medical use as exceptional treatment options since 2014. The Swiss Medical Association for Psychedelic...
Journal of Educational, Health and Community Psychology
March 4, 2025
Niken Titi Pratitis, Lutfi Suryo W
HIV remains a significant global health concern, often increasing the risk of psychological distress, including depression and anxiety. Anxiety, characterized by feelings of unease and excessive worry about future events, may be influenced by mindfulness and resilience. Mindfulness, which enhances present-moment awareness, has been shown to reduce anxiety, while resilience enables individuals...
The Brown University Psychopharmacology Update
March 3, 2025
The stressors that frontline healthcare workers experienced during the COVID-19 pandemic led to widespread burnout, depression, and post-traumatic stress disorder (PTSD). Based on research showing that psychedelic-assisted therapy led to improvement in symptoms of depression in various populations, investigators conducted a randomized clinical trial to evaluate the effects of psilocybin therapy...
Journal of Clinical Medicine
March 3, 2025
Evgenia Gkintoni, Stephanos P. Vassilopoulos, Georgios Nikolaou
64 citations
Background/Objectives: This systematic review outlines the neurocognitive outcomes and mechanisms of mindfulness-based cognitive therapy (MBCT) that influence subjective well-being. MBCT is a clinical intervention that integrates cognitive therapy with mindfulness practices to prevent depression relapses and improve mental health. Methods: The review focuses on the effects of MBCT on brain...
Current reviews in clinical and experimental pharmacology
March 3, 2025
Sin Hui Ng, Yu Zhao Lee, Ming Ye Hong et al.
2 citations
Ketamine, a substance used for anesthesia and known for inducing dissociation, can lead to addiction and the development of severe withdrawal symptoms. Ketamine alters brain networks before affecting somesthetic sensation. Ketamine abuse was especially prevalent in East and Southeast Asia, and its popularity has continued to expand globally in recent decades. Ketamine is gaining popularity in...
The Brown University Psychopharmacology Update
March 1, 2025
Several sensitivity analyses of a Phase 3b trial have demonstrated that esketamine nasal spray was consistently more efficacious than extended‐release quetiapine in patients with treatment‐resistant depression (TRD). The additional analyses of the ESCAPE‐TRD trial used multiple thresholds for remission and relapse. Study results were published online Dec. 2, 2024, in The British Journal of...
Neuropsychopharmacology
March 1, 2025
Ella Williams, Ursule Taujanskaite, Sunjeev K. Kamboj et al.
There is an ongoing need to identify novel pharmacological agents for the effective treatment of depression. One emerging candidate, which has demonstrated rapid-acting antidepressant effects in treatment-resistant groups, is nitrous oxide (N2O)-a gas commonly used for sedation and pain management in clinical settings and with a range of pharmacological effects, including antagonism of NMDA...
Physics of Life Reviews
March 1, 2025
Georg Northoff, Andrea Buccellato, Federico Zilio
31 citations
Despite major progress in our understanding of the brain, the connection of neural and mental features, that is, brain and mind, remains yet elusive. In our 2020 target paper ("Is temporospatial dynamics the 'common currency' of brain and mind? Spatiotemporal Neuroscience") we proposed the "Common currency hypothesis": temporo-spatial dynamics are shared by neural and mental features, providing...
Journal of the Association of Physicians of India
March 1, 2025
Monika Pathania, Madhav Banjade, Meenakshi Khapre et al.
1 citation
Functional dyspepsia (FD) is one of the most common reasons for medical visits. Patients with FD incur large direct and indirect expenditures and may have significant financial burdens that affect quality of life. Our study aimed to assess the effectiveness of meditation as an adjuvant to the standard treatment in individuals diagnosed with FD. This will explore more cost-effective therapeutic...