Mindfulness meditation has demonstrated modest benefits for mental health and well-being, although the relationship between practice dose and outcomes is unclear. Meta-analyses and randomized controlled trials have shown mixed results so far, although such results may stem from methodological issues rather than reflecting the absence of an underlying effect. Research outside structured programs...
Major depressive disorder (MDD) remains a significant global health burden, and its current treatments are limited by the delayed onset of efficacy weeks after dosing. While esketamine and psychedelics were clinically successful as rapid-acting antidepressants in recent years, these molecules are heavily associated with psychotic side effects and the risks of substance abuse. In this study, we...
Latar Belakang: Mindfulness-Based Stress Reduction (MBSR) telah terbukti efektif dalam mengurangi emosi negatif pada berbagai kondisi psikologis. Namun, efektivitasnya dalam konteks pasien bipolar, khususnya yang diberikan oleh perawat, memerlukan perhatian khusus. Tujuan: Menilai efektivitas MBSR yang diterapkan oleh perawat dalam mengurangi emosi negatif pada pasien bipolar melalui...
Background: Child abuse is a widespread issue affecting millions of children worldwide. It can take the form of physical, emotional, or sexual abuse and often leads to lasting psychological harm. Addressing the emotional and mental health needs of survivors is crucial for their long-term well-being. This study explores how Buddhist meditation can help promote psychological healing and...
Abstract Ayahuasca is a psychedelic brew used for centuries in religious rituals by indigenous cultures. Recent studies suggest its potential to reduce depression and anxiety and as an alternative for treating ethanol and tobacco use disorders. However, research on its impact on cocaine use disorder remains limited. We investigated the effects of ayahuasca on the reinstatement of...
Background: Premenstrual dysphoric disorder (PMDD) is a severe mood disorder characterised by depression, irritability, mood lability, anxiety and physical symptoms that occur exclusively in the last week/s of the menstrual cycle. With a growing global interest in microdosing of psychedelic drugs, an increase in self-medication has occurred, including by those with PMDD. Aim: Qualitative...
Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in...
The resurgence of psychedelic-assisted psychotherapy marks a pivotal evolution in mental health treatment, challenging traditional paradigms by integrating compounds such as psilocybin, LSD, MDMA, and ketamine into clinical practice. Historically marginalized due to regulatory and societal concerns, these agents are now gaining recognition for their unique neurobiological mechanisms and...
EMJ spoke with Christina Dalla, a pioneering researcher in neuropsychopharmacology and expert in sex differences in neuropsychiatric disorders, to discuss her most impactful discoveries in depression and anxiety, and the potential of psychedelic treatments in mental health.
Psilocybin's efficacy as a treatment for treatment-resistant depression (TRD) has led to a wave of new legislation permitting its usage in medical settings. Older adults are affected disproportionately by TRD and may be especially good candidates for this promising treatment. However, due to the drug's past (and present) illicit status and exposure to historic antidrug messaging, older...