Abstract Background The evident limitations of current treatments for depression, anxiety and obsessive-compulsive disorder (OCD), underscore the need for a paradigm shift in how we understand and treat these disorders. There is enormous public and research enthusiasm for the potential that psychedelic drugs like psilocybin, the psychoactive compound produced by “magic mushrooms” will drive a...
Abstract Background Psilocybin, the psychoactive compound produced by so-called “magic” mushrooms has shown promise in alleviating symptoms of a range of psychiatric conditions including depression, anxiety and substance use disorder. Recently, a small Phase 1 trial showed psilocybin to be safe and tolerable for individuals with anorexia nervosa (AN), with 4/10 participants experiencing...
A systematic review of electroencephalographic (EEG) correlates of Mindfulness- based treatment for chronic pain is presented. Recent technological advances have made EEG acquisition more accessible and also reliable. EEG monitoring before, during, and after treatment might support efficacy assessment and enable real- time adaptive intervention. The preliminary research extracted 131 papers...
Resilience helps mitigate the negative impacts of stress and promotes effective adaptation in adverse situations. This study investigated the impact of immediate and standardized mindfulness meditation (MM) on the resilience of college students, aiming to offer adaptable MM practices for different stress scenarios. The blood pressure (BP) and heart rate variability (HRV) of 48 participants were...
The K-12 population refers to individuals, primarily aged 6-17, from kindergarten through 12th grade. Drug-related suicidal ideation (SI) in the K-12 population is a major concern. This study aims to identify medications linked to increased SI risk in the K-12 population using the FDA Adverse Event Reporting System (FAERS) database. We extracted cases of SI in individuals aged 6-17 years where...
Ketamine and its enantiomers, esketamine and arketamine, have emerged as promising treatments for treatment-resistant depression (TRD). This cross-sectional study evaluates the regulatory alignment of 40 clinical trials listed on ClinicalTrials.gov, focusing on the methodological challenges. The study highlights methodological inconsistencies, particularly around the challenges of functional...
Psilocybin is a psychedelic serotonergic compound that is renowned for its potent psychoactive effects. Over the past 15 years, an increasing number of controlled clinical trials showed that it has a fast-acting and sustainable efficacy in treating various psychiatric disorders. Neuroimaging studies have been conducted with the objective of elucidating the neurobiological mechanisms underlying...
Natural hallucinogens derived from fungi and animals have been used for centuries in shamanic, ritualistic, and medicinal practices across diverse cultures. These compounds exhibit a widerange of structures and mechanisms of action, affecting various neurotransmitter systems pathways. Fungal hallucinogens, primarily indole alkaloids like psilocybin and ergot alkaloids, as well as animal-derived...
medRxivJuly 29, 2025Yuwen He, Shan Lei, Wangli Si et al.
preprint
Abstract Background Somatic awareness is a fundamental practice for novice mindfulness practitioners. It has been proposed that mindfulness meditation training (MMT) enhances brain function through somatic awareness in both non-clinical and clinical populations. However, the neural signatures underlying this mechanism remain poorly understood. Methods In our study, we conducted mindfulness...