Depression: all studies (page 536) - The Consciousness Library

Esketamine attenuates post-traumatic stress disorder via suppressing neuroinflammation and abnormal myelination.

Neurochemistry International November 19, 2025 Zhaoliang Gu, Ruixue Song, Guoqiang Liu et al. 3 citations

Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of PTSD involves complex neurobiological processes. However, the underlying mechanism is not clear, leading to lack of effective therapeutic interventions. Mice were exposed to the electric foot shocks using the contextual fear memory paradigm. A...

DOI: 10.1016/j.neuint.2025.106089 Full text Fear memory Myelination Neuroinflammation Esketamine For PTSD +1

Ketamine reduces microglial activation and brain monocyte infiltration and promotes peripheral regulatory immune cells, relieving lipopolysaccharide (LPS)-induced depressive-like behavior in mice.

Molecular Psychiatry November 18, 2025 A. Arena, M. R. Rubinstein, A. M. Genaro et al.

Ketamine has emerged as a rapid and sustained treatment for Major Depressive Disorder (MDD) and an alternative for patients who have not responded to traditional therapies. Its effects have been partly attributed to the noncompetitive antagonism of the N-methyl-D-aspartate receptor (NMDAR) in the central nervous system, which enhances neuroplasticity. However, the etiopathology of MDD is...

DOI: 10.1038/s41380-025-03338-w Full text

Airways to Alteration (A2A): a randomised-controlled trial exploring effects of breathwork on conscious state

Research Square November 18, 2025 Guy W. Fincham, Edward Caddye, Amy Kartar et al. preprint

Abstract Breathwork which increases ventilatory rate or depth represents an accessible nonpharmacological modality for potentially inducing altered states of consciousness (ASCs). Despite gaining traction as a therapeutic tool, empirical research remains limited, hence we conducted the first randomised-controlled trial (NCT06916312) on breathwork and ASCs. We examined the effects of a single...

DOI: 10.21203/rs.3.rs-7254002/v1

The effect of mindfulness-based stress reduction on self-compassion and parent-child relationship quality in health caregivers

BMC Psychology November 16, 2025 Tayebeh Rakhshani, Afrooz Bagherfard, Amirhossein Kamyab et al. 1 citation

Abstract Background Women’s increasing workforce participation has led to stress, anxiety, and strained parent-child relationships, highlighting the need for effective interventions. Mindfulness-based stress reduction (MBSR) is a promising yet underutilized approach to improving psychological well-being and parenting quality. This study examines its impact on self-compassion and parent-child...

DOI: 10.1186/s40359-025-03562-7 Full text Self-compassion Mindfulness-based intervention Health caregivers Mbis +13

Qualitative insights into psilocybin and LSD experiences: Enhanced connection and emotion processing reported by Spanish-speaking survey respondents

Psychedelics November 15, 2025 Meghan DellaCrosse, Shoval Gilead, Rafael Lancelotta et al.

Serotonergic psychedelics like psilocybin and LSD have shown potential therapeutic benefits for mental health conditions, including depression, PTSD, and addiction. However, research remains limited due to regulatory barriers and a lack of diversity in study populations. Spanish-speaking individuals, despite their significant global and U.S. presence, are underrepresented in psychedelic...

DOI: 10.1016/j.psyche.2025.100004 Psilocybin Generalizability theory Thematic analysis Mental health +11

(R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats.

Psychopharmacology November 15, 2025 Elisabetta Ciccocioppo, Sara Massetti, Marcus W. Meinhardt et al.

Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alternative treatment for AUD. Among this class of molecules, ketamine, a dissociative psychedelic, shows promising properties. It reduces alcohol drinking in rodents and in humans it is used to...

DOI: 10.1007/s00213-025-06964-y Full text R-ketamine Psychedelics Dissociative psychedelic Reducing alcohol intake +8

The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents

Molecular Psychiatry November 14, 2025 Núria Nadal‐gratacós, Pol Puigseslloses, Laura Hernández‐guzmán et al.

Psychedelics have garnered significant interest for their therapeutic potential in mental health conditions such as depression, anxiety, and post-traumatic stress disorder. While research has primarily focused on well-studied psychedelics, phenethylamine derivatives have also gathered interest for their potential therapeutic applications. Thus, this study aims to investigate the pharmacological...

DOI: 10.1038/s41380-025-03341-1 Full text Phenethylamine Antidepressant Dopamine Reboxetine +8

Effects of Buspirone Combined with Mindfulness-Based Cognitive Therapy on Emotional Improvement, Sleep Quality, and Serum Cortisol Level in Patients with Generalized Anxiety Disorder.

Psychiatry and Clinical Psychopharmacology November 13, 2025 Yimeng Ma, Zhiguo Ge, Xinyan Wu

Background: Buspirone shows a certain efficacy in patients with generalized anxiety disorder (GAD), but its combination therapy with mindfulness-based cognitive therapy (MBCT) remains unclear. To compare buspirone + MBCT versus buspirone alone for GAD in a retrospective cohort. Methods: According to the treatment regimens, patients were assigned to the experimental group (n = 50) to receive 120...

DOI: 10.5152/pcp.2025.251242

Molecules, Memory, and the Mind: Psychedelics and the Future of Neuroplasticity

Berkeley Scientific Journal November 13, 2025 Ana Sofia Brito

Interview with Dr. Andrea Gomez

DOI: 10.5070/bs329265621 Full text Neuroplasticity Nervous system Neural activity

Open-label Prospective, Interventional Study Assessing Efficacy and Safety of Intramuscular Ketamine for Suicidal Ideation in a Tertiary Care Hospital.

Indian Journal of Psychological Medicine November 13, 2025 Malika M Sanspara, Drashti M Shah, Sandip H Shah et al.

This study evaluated intramuscular (IM) ketamine's efficacy and safety for rapid suicidal ideation reduction, addressing the critical need for fast-acting interventions in resource-limited settings where intravenous (IV) options are impractical. We conducted a pre-post-interventional study of IM ketamine (0.5 mg/kg) over one year after approval of the institutional ethics committee. Adult...

DOI: 10.1177/02537176251389117 Full text Intramuscular ketamine Madrs-si Rapid intervention Treatment +10