Objectives: Women experiencing infertility report heightened levels of anxiety, depression, and distress. However, access to affordable mental health care is limited in most areas of the world. Self-directed interventions, including bibliotherapy and mobile app-delivered interventions, provide a potentially cost-effective option for the treatment of infertility-related distress. This study...
This single-case study examines the impact of a 6-week Mindfulness-Based Intervention (MBI) on an individual experiencing anxiety, with a particular focus on intolerance of uncertainty (IU). A mixed-methods approach was used, combining quantitative measures with qualitative data from session notes, interviews, and participant feedback. Quantitative findings indicated reductions in stress...
Molecules and CellsMarch 10, 2026Victoria N. Chang, Roberto Ogelman, R. Vargas et al.1 citation
Excitatory synapse plasticity at postsynaptic dendritic spines is directly modulated through neurotransmitter signaling. Serotonin (5-HT) is a primary neuromodulator in the brain that activates 14 subtypes of G-protein-coupled receptors, each with distinct expression patterns and downstream signaling mechanisms. Disruptions of serotonergic transmission during development and adulthood induce...
Research SquareMarch 10, 2026Giammarco di Gregorio, Sophia Basset, Harjot Manmohan et al.
preprint
Abstract Depression and anxiety affect one in five adults, with age affecting prevalence. While clinical trials suggest classic psychedelics (e.g., psilocybin, LSD) and non-classic psychedelics (e.g., MDMA, ketamine) may alleviate these symptoms, it remains unclear how these relationships function in naturalistic settings or how they vary across the lifespan. We conducted a cross-sectional...
Background Though esketamine was approved by the Food and Drug Administration (FDA) for treatment-resistant depression in 2019, there is no published research on implementation challenges. Therefore, the aim of this study was to investigate online commentary about these challenges among mental healthcare providers. Methods Using the terms “esketamine” and “Spravato”, the author searched social...
BACKGROUND: Non-suicidal self-injury (NSSI) is highly prevalent among individuals with borderline personality disorder (BPD) and a robust predictor of future suicide attempts and death. Access to comprehensive treatments such as dialectical behaviour therapy remains limited. METHODS: This exploratory study evaluated the feasibility and preliminary outcomes of a brief, group-based...
For over 2500 years, the aim of Buddhism has been to help people liberate themselves from suffering, attain happiness and well-being, and ultimately achieve Nirvana, the path to freedom. Many Buddhist practices in emotional management are effective in alleviating suffering. Among these, meditation, mindfulness, and compassion meditation, due to their effects on improving concentration, calming...
BACKGROUND/OBJECTIVES: Mindfulness-based interventions (MBIs) have shown promising effects across diverse areas of psychiatry, yet their specific role in bereavement remains insufficiently synthesized. Bereavement is a universal but heterogeneous process, with a minority of individuals at risk of developing prolonged grief disorder (PGD). Understanding the potential benefits of MBIs in this...
Abstract Psilocybin, a serotonergic psychedelic, can produce rapid and enduring antidepressant effects in patients with major depressive disorder (MDD)[1, 2], yet the neural mechanisms underlying these effects remain unclear. Negative affective biases are an important neuropsychological mechanism central to the development and perpetuation of MDD[3]. Using a translational rodent model, we...
Background: The Default Mode Network (DMN) is consistently implicated in self-referential thinking and rumination and shows altered functioning in depression and anxiety disorders. The Attention Training Task (ATT), a core technique in metacognitive therapy, aims to reduce internally directed attention by enhancing flexible attentional control. While previous neuroimaging studies have...