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Depression: all studies

Page 426 of 1,034: studies 4,251 to 4,260 of 10,336, newest first. Back to the depression overview

Research

The Impact of Trait Mindfulness on Quality of Life in Patients With Bipolar Disorder: The Serial Mediating Role of Emotion Dysregulation and Depressive/Manic Symptoms

Actas Españolas de Psiquiatría October 15, 2026 Yangyang Xu

Background: To explore the impact of trait mindfulness on the quality of life (QoL) in patients with bipolar disorder (BD) and to examine the serial mediating roles of emotion dysregulation and depressive/manic symptoms. Methods: A cross-sectional study based on previous medical record data was conducted. Clinical records and scale data of 256 patients with BD who received outpatient or...

Nature-based mindfulness program for parents and caregivers: a mixed-methods study

Frontiers in Psychology October 15, 2026 Zoe Jiwen Zhang, Herman Hay Ming Lo, Wai Fong Lok et al.

Introduction There is a growing interest in incorporating nature into mindfulness-based programs. This study is unique as it targets parents and family caregivers experiencing caregiving stress. Methods A mixed-methods study was conducted to evaluate the outcome of a nature-based mindfulness intervention program. A comprehensive outcome measures targeting benefits of parents and caregivers,...

Aspirational Autonomy and Psychedelic-Assisted Therapy in Advanced Cancer: Ethical Lessons from Clinical Cases.

The oncologist October 15, 2026 Keenan Wills Davis, Michelle C. Bach, JoEllen Schimmels et al.

Psychedelic-assisted therapy (PAT) is increasingly discussed as a potential intervention for anxiety, depression, and existential distress among patients with advanced cancer. Yet the ethical challenges of PAT for patients approaching the end of life remain underdeveloped, particularly for oncologists who may be asked to counsel patients or consider referral to clinical trials. This article...

Clinical and neurophysiological effects of imagery rehearsal therapy and targeted memory reactivation in post-traumatic stress disorder

Research Square October 14, 2026 Océane Lüthi, Vincent Rochas, Audrey Theux et al. preprint

Abstract Post-traumatic stress disorder is frequently associated with post-traumatic nightmares, which may be related to cortical hyperarousal. Imagery Rehearsal Therapy is the first-line treatment for nightmares. Targeted Memory Reactivation, which reactivates specific memories during sleep to enhance memory consolidation, has been shown to enhance the effects of Imagery Rehearsal Therapy in...

Feasibility of implementing a mindfulness-based program for paediatric intensive care unit staff

Australian Critical Care October 14, 2026 Rahul Joshi, Gayatri Marwah, Sainath Raman et al.

BACKGROUND: Paediatric intensive care unit (PICU) clinicians are particularly susceptible to workplace stress due to frequent ethical dilemmas (for example, perceptions of futile or unethical treatment), patient morbidity and mortality, sleep disruption, and emotional exhaustion, putting them at increased risk of anxiety, depression, and burnout. The psychological well-being of these healthcare...

Mechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream Pathways

CNS & Neurological Disorders - Drug Targets October 14, 2026 Sheekha Chaudhary, Sanchit Dhankhar, Monika Saini et al.

More than fifty million individuals worldwide are experiencing neurodegenerative disorders, which include Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis, and frontotemporal dementia. These disorders have a significant role in the gradual degradation of cognition and motor skills. Most current treatment approaches have little...

AI-assisted characterization of psychedelic clinical trials from ClinicalTrials.gov

Trials October 14, 2026 Luca Pani, Fabio Tascedda

Abstract: Background: The registry record of psychedelic and related rapid-acting compounds is large, heterogeneous and laborious to synthesize by hand. We tested whether a large language model (LLM) with live access to the ClinicalTrials.gov application programming interface (API) could produce a timely, structured and reproducible characterization of this landscape. Methods: Cross-sectional...

Participant experiences and recommendations for psychedelic clinical trials and future treatment delivery: a qualitative study with experts by experience from the Psychedelic Participant Advocacy Network

Frontiers in Psychiatry October 14, 2026 Mathieu Seynaeve, Leonie Schneider, Ian Roullier et al.

BackgroundWhile psychedelic treatments for difficult-to-treat mental health conditions are advancing, participant perspectives remain under-explored. This study examined former participants’ experiences across recruitment, preparation, dosing, integration and study ending, and generated recommendations for future trials and treatment delivery.MethodsThis qualitative descriptive study, informed...

Intervenciones de mindfulness y propuesta de aplicación para el acoso laboral

Revista horizonte académico October 13, 2026 Franchesca Zadoth Jane Nieto Ferrer

Este informe presenta un análisis documental secundario de un único ensayo controlado aleatorizado publicado, que evaluó la eficacia de intervenciones de mindfulness en estudiantes universitarios durante la pandemia de COVID-19, comparando tres modalidades -presencial, basada en aplicación móvil y combinada- frente a un grupo control activo que recibió formación en comunicación. El objetivo fue...

Psychedelic-Induced Changes in Personality Traits: A Systematic Review

Roczniki Psychologiczne October 13, 2026 Patrycja Bartkiewicz, Wojciech Baran, Ewelina Lachowska

An increasing number of studies have examined the effects of psychedelics on mental wellbeing and their potential use as adjunctive therapy for depressive and anxiety disorders. In this review, we compiled research from the past ten years that focused specifically on the impact of psychedelic use on personality traits. A systematic search was conducted across the databases Web of Science,...