Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments. Pathophysiology in MDD has highlighted the N-methyl-D-aspartate (NMDA) glutamatergic system as a promising therapeutic target. In 2022, the US Food and Drug Administration...
Spirituality is a crucial yet complex element of holistic nursing care, particularly when providing care for older adults with depression. In Thailand, depression poses a significant mental health challenge. Thai cultural values are deeply interwoven with individuals' beliefs, making spirituality a critical factor in addressing the care of older adults with depression. This study aimed to...
This study evaluated the effects of the Mindfulness-Based Blood Pressure Reduction (MB-BP) program on depression symptoms in individuals with elevated blood pressure (BP). Exploratory analyses examined whether childhood abuse or neglect moderated these effects. Adults with elevated BP (n = 201; ≥120/80 mmHg) were randomized to MB-BP (n = 101) or enhanced usual care (n = 100) and followed for 6...
Depression is a highly prevalent and incident mental illness. Current pharmacological therapies fail in approximately 30-40% of patients, highlighting the urgent need for novel agents with pleiotropic effects. This preclinical study aimed to identify new antidepressants and cognitive modulators among five phytocannabinoids: cannabichromene, cannabidiol, cannabidivarin, cannabigerol and...
AIM This updated systematic review and meta-analysis aimed to evaluate the effectiveness of mindfulness-based interventions (MBIs) in reducing stress, anxiety, depression and improving mindfulness among nursing students. BACKGROUND Nursing students often experience significant psychological distress due to the demanding academic and clinical environments of nursing education. MBIs have been...
PregnancyMay 2026Riane Bradbury-Huang, Lindsay Quinn, Ellen L Tilden et al.
Previous research has shown that preventive counseling for women at high risk of perinatal depression leads to a reduction in the development of perinatal depression and is cost-effective. Barriers of cost, transit, time, and staffing limit accessibility of these services. We examined whether a theoretical, virtual, group, social worker (SW)-led Mindfulness-Based Cognitive Therapy (MBCT)...
This study used a daily diary method to examine the temporal relationship between distress tolerance (DT), anxiety, and depression during a mindfulness-based intervention (MBI). A total of 83 participants with high emotional distress completed daily diaries of mindfulness, DT, anxiety and depression over one week before, during, and after the intervention. Linear mixed models showed significant...
Introduction: Recent rapid technological advancements and societal changes have dramatically transformed modern life, leading to a significant increase in mental health concerns. Meditation, an ancient practice, has gained considerable attention in recent years for its psychological and neurological benefits. Aim: To compare levels of depression, anxiety and stress between Meditation...
To synthesize evidence on pharmacological treatments for major depressive disorder (MDD) to inform updated Brazilian clinical guidelines. This overview included systematic reviews and meta-analyses published in the last 10 years, identified through MEDLINE, Cochrane Library, and SciELO. Eligible studies involved adults with MDD receiving pharmacological interventions. Risk of bias was assessed...
Cancer ReportsMay 1, 2026Sepideh Hajivalizadeh, Kimia Farahmand, Kimia Kazemzadeh et al.
Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism-based framework for managing cancer-related depression by exploring its unique pathophysiology and evaluating promising pharmacotherapies based on their alignment with these biological pathways. This narrative review synthesized evidence on promising...