Translational Psychiatry
February 17, 2015
James W. Murrough, Katherine A. Collins, Jessica Fields et al.
111 citations
The glutamate N-methyl-D-aspartate receptor antagonist ketamine has demonstrated antidepressant effects in individuals with treatment-resistant major depressive disorder (TRD) within 24 h of a single dose. The current study utilized functional magnetic resonance imaging (fMRI) and two separate emotion perception tasks to examine the neural effects of ketamine in patients with TRD. One task used...
Journal of Psychopharmacology
February 17, 2015
Níall Lally, Allison C. Nugent, David A. Luckenbaugh et al.
224 citations
Anhedonia is a cardinal symptom of major depression and is often refractory to standard treatment, yet no approved medication for this specific symptom exists. In this exploratory re-analysis, we assessed whether administration of rapid-acting antidepressant ketamine was associated specifically with reduced anhedonia in medication-free treatment-refractory patients with major depressive...
BMC Psychiatry
February 5, 2015
Hong Gong, Chenxu Ni, Xiaoliang Shen et al.
Prenatal depression can negatively affect the physical and mental health of both mother and fetus. The aim of this study was to determine the effectiveness of yoga as an intervention in the management of prenatal depression. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted by searching PubMed, Embase, the Cochrane Library and PsycINFO from all retrieved...
Annals of the New York Academy of Sciences
February 3, 2015
Kaitlin E. DeWilde, Cara F. Levitch, James W. Murrough et al.
Major depressive disorder (MDD) is one of the most disabling diseases worldwide and is becoming a significant public health threat. Current treatments for MDD primarily consist of monoamine‐targeting agents and have limited efficacy. However, the glutamate neurotransmitter system has recently come into focus as a promising alternative for novel antidepressant treatments. We review the current...
Journal of Intellectual Disability Research
February 1, 2015
H. Idusohan‐Moizer, A. Sawicka, J. Dendle et al.
Abstract: Background: Mindfulness‐based interventions have been shown to be effective in the treatment of a range of health and psychological disorders in adults and young people without intellectual disabilities (ID). Clinical studies are emerging reporting on the efficacy of mindfulness‐based interventions as a stand‐alone treatment for common clinical disorders in adults withID. Method: This...
Cognitive Neurodynamics
February 2015
Poppy L A Schoenberg, Anne E. M. Speckens
To illuminate candidate neural working mechanisms of Mindfulness-Based Cognitive Therapy (MBCT) in the treatment of recurrent depressive disorder, parallel to the potential interplays between modulations in electro-cortical dynamics and depressive symptom severity and self-compassionate experience. Linear and nonlinear α and γ EEG oscillatory dynamics were examined concomitant to an affective...
Journal of Affective Disorders
January 15, 2015
Giovanni Stanghellini, Andrea Raballo
It is a current trend in psychiatry to discard the Kraepelinian dichotomy schizophrenia vs. manic-depressive illness and use the overinclusive label 'psychosis' to broadly indicate the whole spectrum of severe mental disorders. In this paper we show that the characteristics of psychotic symptoms vary across different diagnostic categories. We compare delusions in schizophrenia and major...
Frontiers in Psychology
January 12, 2015
Alberto Amutio, Clemente Franco, María de Carmen Pérez-Fuentes et al.
Fibromyalgia is a disabling syndrome. Results obtained with different therapies are very limited to date. The goal of this study was to verify whether the application of a mindfulness-based training program was effective in modifying anger, anxiety, and depression levels in a group of women diagnosed with fibromyalgia. This study is an experimental trial that employed a waiting list control...
Integrative Cancer Therapies
2015
C. Eyles, G. Leydon, C. Hoffman et al.
The impact of living with metastatic breast cancer (MBC) is considerable and psychosocial support can be beneficial. Mindfulness-based stress reduction (MBSR) can help self-management of anxiety, depression, quality of life (QoL), and fatigue and has been evaluated in early-stage breast cancer but not MBC. This study investigated the acceptability and feasibility of providing MBSR for women...
RAND Corporation eBooks
2015
Melony E. Sorbero, Sangeeta C. Ahluwalia, Kerry A. Reynolds et al.
RAND researchers conducted a systematic review that synthesized evidence from randomized controlled trials of mindfulness-based cognitive therapy — used adjunctively or as monotherapy — to assess its efficacy and safety in treating adults with major depressive disorder (MDD).