Ketamine Safety and Tolerability in Clinical Trials for Treatment-Resistant Depression
The Journal of Clinical Psychiatry September 2, 2014 Le-Ben Wan, Cara F. Levitch, Andrew M. Perez et al. 232 citations
OBJECTIVE: Ketamine has demonstrated rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this population have not been fully described. Herein we report the largest study to date of the safety, tolerability, and acceptability of ketamine in TRD. METHOD: Data from 205 intravenous (IV) ketamine infusions (0.5...