Psychiatry Research
May 1, 1984
I Trenholme, R D Cartwright, G Greenberg
Dreams reported from laboratory awakening of stably married women differed from those of women undergoing divorce: The former dreamed of the experiment; the latter had more threat themes. Those coping well during the divorce had more positive motives in the last dream than those who were depressed. Dreams of the nondepressed divorcées increased in anxiety from first to last dream report,...
Peptides
1984
R Quirion, D A DiMaggio, E D French et al.
Porcine brain contained an active factor that competed with [3H]-phencyclidine (PCP) for binding to rat brain membranes. On reverse phase high pressure liquid chromatography, the active material eluted between 38-42% acetonitrile. Gel filtration chromatography of the factor predicted a molecular weight of approximately 3000 daltons. The endogenous substance appeared to be selective for PCP...
Revue d'electroencephalographie et de neurophysiologie clinique
November 1, 1982
M Timsit-Berthier, H Mantanus, D Dethier et al.
The present study constitutes an approach to the action mechanisms of nitrous oxide (N2O) by assessing both the subjective effects induced by the inhalation of this anaesthetic gas, and their electrophysiological correlates, i.e., spontaneous EEG, analyzed by a Fourier algorithm, AEP and CNV. The experiment was conducted single blind in 9 volunteers under 3 recording conditions: inhalation of...
European Journal of Pharmacology
July 30, 1982
J Heym, G F Steinfels, Barry L. Jacobs
21 citations
A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus (NRP) of freely moving cats. NRP neurons were substantially less responsive than DRN neurons to both drugs. NRP neurons were unresponsive to behaviorally effective low doses of these drugs whereas the activity of DRN neurons was strongly depressed....
Journal of Pharmacology and Experimental Therapeutics
March 1, 1982
P. Lalley
5-Methoxy-N,N-dimethyltryptamine (20-200 microgram/kg) inhibits phrenic and sympathetic neural discharges and depresses blood pressure. The effects occur within seconds after injection. Complete recovery occurs, on the average, after 20 min. The inhibition of phrenic nerve discharges is prevented during hypercapnia and hyperthermia and reversed during 50 Hz electrical stimulation of the carotid...
Neuroscience & Biobehavioral Reviews
1982
Randall L. Commissaris, M Davis
25 citations
The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the acoustic startle response in the rat. Systemic administration of these agents, which distributes to both the brain and spinal cord, produced opposite effects, as DMT depressed and 5-MeODMT...
Psychological Reports
December 1, 1981
Stephen M. Rivers, Nicholas P. Spaños
12 citations
147 students were assessed on absorption, hypnotic susceptibility, and three measures of “psychological well-being” (self-esteem, depressive affect, psychosomatic symptoms) and were then invited to participate without cost in a program to learn meditation. Those completing the four-session training program were followed for 5 mo. by phone and mail. Analysis indicated that (a) meditating...
Brain Research
June 1, 1981
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of several hallucinogenic drugs while concurrently monitoring the activity of raphe neurons in freely moving cats. LSD produced a dose-dependent decrease in raphe unit activity and a dose-dependent increase in...
Pharmacology, Biochemistry, and Behavior
May 1, 1981
Randall L. Commissaris, William H. Lyness, Richard H. Rech
29 citations
The purpose of the present study was to determine the role of central 5-hydroxytryptamine (5-HT) neuronal systems in the effects of d-lysergic acid diethylamide (LSD), 2,5-methoxy-4-methylamphetamine (DOM), pentobarbital (PB) and methaqualone (MQ) on punished responding in rats. Water-deprived rats were trained to drink from a tube that was electrified at intervals (variable interval 21 sec;...
The British Journal of Psychiatry
September 1980
S A Checkley, Robin Murray, M C Oon et al.
The excretion of N,N,-dimethyltryptamine (DMT) has been measured in longitudinal studies of five patients with schizophrenic illnesses and in four patients with rapidly or slowly cycling manic-depressive illness. The excretion of DMT was frequently raised in patients when they were psychotic but was usually normal when they had recovered. However, rapid changes in the severity of illness or...