The Journal of Neuropsychiatry and Clinical Neurosciences
August 1, 1997
278 citations
Religious experience is brain-based, like all human experience. Clues to the neural substrates of religious-numinous experience may be gleaned from temporolimbic epilepsy, near-death experiences, and hallucinogen ingestion. These brain disorders and conditions may produce depersonalization, derealization, ecstasy, a sense of timelessness and spacelessness, and other experiences that foster...
Addiction
July 1, 1997
Valerie H. Curran, Ross A. Travill
283 citations
Abstract Aims. Recreational use of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widespread. The present study aimed to examine both the acute and residual effects of this drug on users' mood and cognitive Junction. Design and participants. A parallel group design was used to compare 12 participants who reported having taken MDMA with 12 participants who reported having consumed only...
Human Psychopharmacology: Clinical and Experimental
May 1, 1997
D. Davison, A. C. Parrott
136 citations
Twenty recreational drug users were asked to describe the psychological and physiological effects they experienced under MDMA (3,4-methylenedioxymethamphetamine). The subjects comprised 11 males and nine females, in the age range 18–31 years. Five subjects had taken MDMA once, nine had taken it 2–9 times, while six subjects had taken it +10 times. Each subject completed a modified Profile of...
Annals of Clinical Psychiatry
March 1, 1997
Timothy D Brewerton
11 citations
Psychosis commonly occurs as a direct result of complex partial seizure disorder (CPSD). This organic mental disorder is indeed "complex" and is easily and frequently misdiagnosed as a variety of functional disorders, including schizophrenia, schizoaffective disorder, bipolar illness, psychotic depression, and, at best, "atypical psychosis." However, this important clinical syndrome has several...
Fortschritte der Neurologie · Psychiatrie
February 1, 1997
Rainer Thomasius, Margit Schmolke, Dana Kraus
Epidemiological research and Substance Abuse Warning Systems point to a sharp increase in the use of "Ecstasy" (MDMA), as well as to structural changes in the drug scene in and outside Europe. For some consumers, "Ecstasy" opens the door to the abuse of other illegal substances. Since the mid-eighties psychiatric complications and consequences of the abuse of MDMA have been reported in at least...
Depression and Anxiety
1997
J. Silvestre, R. Nadal, M. Pallarés et al.
Although noncompetitive NMDA receptor antagonists have shown an anxiolyticlike profile in several studies, such effects have not been observed consistently. Previous studies with ketamine, a noncompetitive NMDA antagonist, have employed only shock tests of anxiety based on conflict procedures. In the present experiment, the effect of an acute low dose of ketamine (7 mg/kg) was examined in adult...
Brain Research Bulletin
1997
S B Kombian, T M Saleh, N I Fiagbe et al.
14 citations
Ibogaine is a natural alkaloid of Voacanga africana that is effective in the treatment of withdrawal symptoms and craving in drug addicts. As the synaptic and cellular basis of ibogaine's actions are not well understood, this study tested the hypothesis that ibogaine and Voacanga africana extract modulate neuronal excitability and synaptic transmission in the parabrachial nucleus using the...
Progress in Neurobiology
August 1996
S R White, T Obradovic, K M Imel et al.
Methylenedioxymethamphetamine (MDMA, Ecstasy) is a popular recreationally used drug among young people in Europe and North America. The recent surge in use of MDMA and increasing concerns about possible toxic effects of the drug have inspired a great deal of research into the mechanisms by which the drug may affect the central nervous system. This paper reviews studies on the neurochemical,...
The American journal of cardiology
April 15, 1996
J W Zamarra, Robert H Schneider, I Besseghini et al.
Twenty-one patients with documented coronary artery disease were tested at baseline by exercise tolerance testing, and assigned to either stress reduction using the Transcendental Meditation (TM) program or to a wait-list control, After 8 months, the TM group had a 14.7% increase in exercise tolerance, an 11.7% increase in maximal workload, an 18% delay in onset of ST-segment depression, and...
Psychopharmacology
March 1996
J H Kehne, R A Padich, T C McCloskey et al.
Increasing evidence suggests an important role for serotonin (5-HT) neurons in the etiology and treatment of schizophrenia. The prepulse inhibition paradigm is used as a model for sensorimotor gating processes that are disrupted in schizophrenia. The present study assessed the general role of 5-HT in modulating auditory and visual prepulse inhibition in Wistar rats. A general overactivation of...