Journal of Neurochemistry
August 1, 1989
Donna M. Stone, Glen R. Hanson, James W. Gibb
Abstract: The activity of tryptophan hydroxylase (EC 1.14.16.4) from rat brain was significantly decreased 1 h following a single systemic injection of 3,4‐methylenedioxy‐methamphetamine (MDMA) when assessed ex vivo by ra‐dioenzymatic assay or in vivo by the quantitation of 5‐hy‐droxytryptophan accumulation following central L‐aromatic amino acid decarboxylase inhibition. Recovery of enzymatic...
Journal of Near-Death Studies
1989
Dan Punzak
Though near-death studies have yielded few practical applica tions, some psychotherapists have used insights from near-death experiences (NDEs) to treat a variety of problems.Using hypnosis, relaxation methods, or electric shock to initiate a conversation with a purported spirit "possessing" the patient, the therapist persuades the spirit to join others in a land of ethereal beauty and light...
Psychopharmacology
1989
L J Herberg, I C Rose
MK-801 is a ligand at phencyclidine recognition sites associated with NMDA-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate/aspartate (NMDA-type) receptors. Low doses (10-100 micrograms/kg IP) produced a dose-related and prolonged (greater than 1 h) enhancement of variable-interval self-stimulation responding. Higher doses (300 micrograms/kg)...
Pharmacology, Biochemistry, and Behavior
1989
Janis T. Eells, Douglas M. Wilkison
10 citations
The effects of mescaline and LSD on the flash-evoked cortical potential (FEP) were determined in unrestrained rats with chronically-implanted electrodes. Systemic administration of mescaline or LSD significantly attenuated the primary component of the FEP at three stimulus intensities with the greatest effect observed 60-90 minutes following drug administration. The magnitude and specificity of...
Life Sciences
1989
Ramesh Arora, Herbert Y. Meltzer
175 citations
3H-Lysergic acid diethylamide (3H-LSD) binding, a putative measure of 5-HT2 receptor binding, was studied in the blood platelets of 29 depressed patients and 24 normal controls. The Bmax (maximum number of 3H-LSD binding sites) in the blood platelets of depressed patients was significantly greater than that of normal volunteers. This increase in Bmax was due to an increase in female depressed...
International Journal of Neuroscience
November 1, 1988
M A Gillman
The euphorogenic and sexual effects of analgesic nitrous oxide have been long reported anecdotally; however, these effects have only recently been investigated scientifically. The effects of oxygen and analgesic nitrous oxide on sexual arousal provoked by visual erotic stimulation in male (n = 7) and female (n = 6) subjects, using both subjective and objective measures were assessed. Nitrous...
Imagination, Cognition and Personality
October 1, 1988
Paul R. Robbins, Roland H. Tanck
The study examined the relation between depressed mood and dream report. Levels of depressed mood were assessed nightly on a sample of ninety college students over a ten-day period using a structured diary. Dream reports were obtained each morning during the ten-day period. Depressed mood tended to be higher preceding nights for which dreams were recalled and described than for nights in which...
Anesthesiology
August 1988
D W Davis, A M Mans, J F Biebuyck et al.
The purpose of this study was to determine the effect of different doses of ketamine on cerebral function at the level of individual brain structures as reflected by glucose use. Rats received either 5 or 30 mg/kg ketamine intravenously as a loading dose, followed by an infusion to maintain a steady-state level of the drug. An additional group received 30 mg/kg as a single injection only, and...
Neuroscience Letters
July 19, 1988
P K Eide, K Hole
11 citations
The effect of intrathecal (i.th.) substance P (SP) on antinociception elicited by the serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) was investigated in mice by means of the tail-flick method. Substance P (0.07, 0.7 or 7 micrograms) induced a behavioral syndrome for 1-2 min, but had no apparent toxic or neurologic effects and did not alter the tail-flick response...
Journal of Pharmacology and Experimental Therapeutics
June 1, 1988
Wouter Koek, James H Woods, Gail Winger
The behavioral effects of MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)cyclohepten-5,10-imin e], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were compared to those of phencyclidine (PCP). In pigeons, MK-801 produced PCP-like catalepsy (i.e., loss of righting without eye closure and without muscle relaxation) and PCP-like discriminative stimulus effects. In rats,...