Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients
Ramesh Arora, Herbert Y. Meltzer
Life Sciences 1989 DOI: 10.1016/0024-3205(89)90384-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 53 |
| Population | Depressed patients and normal controls |
| Topics | LSD Serotonin |
| Keywords | Platelet Imipramine Endocrinology Significant difference Binding site 5-ht2 receptor 5-HT Receptor |
| Citations | 175 |
| Key findings | The maximum number of 3H-LSD binding sites (Bmax) in blood platelets was significantly greater in depressed patients than in normal controls, an increase attributable to female depressed patients. |
Abstract
3H-Lysergic acid diethylamide (3H-LSD) binding, a putative measure of 5-HT2 receptor binding, was studied in the blood platelets of 29 depressed patients and 24 normal controls. The Bmax (maximum number of 3H-LSD binding sites) in the blood platelets of depressed patients was significantly greater than that of normal volunteers. This increase in Bmax was due to an increase in female depressed patients only. Bmax was significantly lower in female compared to male normal controls but there was no difference between male and female depressed patients. There was also no difference in Kd (an inverse measure of affinity of 3H-LSD binding to its sites) between normal controls and depressed patients. The correlations between Bmax of 3H-LSD binding and the Bmax of the 3H-imipramine binding site or the Vmax of 5-HT uptake sites were not significant. The role of serotonergic processes in the psychobiology of depression is discussed.
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